Structural Aspects of Antioxidant and Genotoxic Activities of Two Flavonoids Obtained from Ethanolic Extract of Combretum leprosum

Table 5

Induction of reversion of point mutation for his1-798, ochre allele lys1-1, and frameshift mutation (hom3-10) in S. cerevisiae haploid strain XV185-14c after treatment with crude ethanolic extract of C. leprosum.

Agent	Treatment (μg/mL)	Survival (%)	LYS1/10^8 survivors	HIS1/10^7 survivors	HOM3/10^8 survivors
STAT cells treated in PBS
NC	0	100.00	4.00 ± 2.83	10.50 ± 0.71	4.00 ± 1.41
4-NQO	1.0 μg/mL	39.97	20.85 ± 2.48	49.50 ± 9.19	13.50 ± 4.95
C. leprosum	10 μg/mL	94.70	7.50 ± 0.71	12.25 ± 0.25	4.00 ± 2.83
	50 μg/mL	91.73	8.00 ± 1.41	12.50 ± 0.71	5.50 ± 2.12
	100 μg/mL	91.73	7.50 ± 2.12	12 ± 2.83	5.00 ± 2.83
	500 μg/mL	88.33	10.50 ± 2.12	27.00 ± 7.07	6.00 ± 2.83

Locus-specific revertants. Locus nonspecific revertants. Mean and standard deviation per three independent experiments. Negative control (solvent). Positive control. Data significant in relation to negative control group (solvent) at ; /one-way ANOVA, Tukey’s multiple comparison test.