Structural Aspects of Antioxidant and Genotoxic Activities of Two Flavonoids Obtained from Ethanolic Extract of Combretum leprosum

Table 6

Induction of reversion of point mutation for his1-798, ochre allele lys1-1, and frameshift mutation (hom3-10) in S. cerevisiae haploid strain XV185-14c after treatment with FCL2 isolated product from ethanolic extract of C. leprosum.

Agent	Treatment (μg/mL)	Survival (%)	LYS1/10^8 survivors	HIS1/10^7 survivors	HOM3/10^8 survivors
STAT cells treated in PBS
NC	0	100.00	4.00 ± 2.83	10.50 ± 0.71	4.0 ± 1.41
4-NQO	1.0 μg/mL	39.97	20.85 ± 2.48	49.50 ± 9.19	13.50 ± 4.95
FCL2	10 μg/mL	98.00	4.00 ± 1.41	10.25 ± 1.77	6.00 ± 1.42
	50 μg/mL	93.03	5.50 ± 2.12	13.15 ± 1.20	5.00 ± 2.83
	100 μg/mL	81.70	7.50 ± 2.12	10.20 ± 4.24	5.00 ± 1.44
	500 μg/mL	82.50	8.50 ± 0.71	10.65 ± 6.29	3.50 ± 2.12

Locus-specific revertants. Locus nonspecific revertants. Mean and standard deviation per three independent experiments. Negative control (solvent). Positive control. Data significant in relation to negative control group (solvent) at ; /one-way ANOVA, Tukey’s multiple comparison test.