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Evidence-Based Complementary and Alternative Medicine
Volume 2017, Article ID 1052125, 11 pages
https://doi.org/10.1155/2017/1052125
Research Article

The Antigastric Cancer Activity of San Leng Powder Extract Induces Apoptosis in Balb/C Bearing-SGC-7901 Mice

1Integrated TCM & Western Medicine Department, Jiangsu Cancer Hospital, Jiangsu Institute of Cancer Research, Nanjing Medical University Affiliated Cancer Hospital, Nanjing, Jiangsu 210000, China
2Pain Department, Jiangsu Cancer Hospital, Jiangsu Institute of Cancer Research, Nanjing Medical University Affiliated Cancer Hospital, Nanjing, Jiangsu 210000, China
3Internal Medicine-Oncology, Jiangsu Cancer Hospital, Jiangsu Institute of Cancer Research, Nanjing Medical University Affiliated Cancer Hospital, Nanjing, Jiangsu 210000, China
4Clinical Pharmacology Base, Jiangsu Province Traditional Chinese Medicine Hospital, Nanjing, Jiangsu 210000, China
5Nanjing Source Origin Biotechnology Co., Ltd., Nanjing, Jiangsu 210000, China

Correspondence should be addressed to Ai-Jun Ji; moc.361@eciffojaj

Received 18 December 2016; Revised 13 March 2017; Accepted 22 March 2017; Published 8 May 2017

Academic Editor: Evan P. Cherniack

Copyright © 2017 Chen Yu et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

San Leng powder extract has been used as medicinal compound for the prevention and treatment of cancers. The antitumor activity of SLPE was determined by treating BALB/C mice harboring a human gastric cancer xenograft with SPLE for 17 days. Mice were also treated with fluorouracil (5-Fu, 25 mg/kg) or a combination of SLPE and 5-Fu. Our results indicate that the inhibition of tumor growth by SLPE might be due to a block in the cell cycle and the induction of apoptosis. These results suggest that SLPE might be useful in the treatment of gastric cancer.