Oral Administration of Red Ginseng Extract Promotes Neurorestoration after Compressive Spinal Cord Injury in Rats
Oral administration of RGE ameliorated morphological damage to spinal cord at 14 days after SCI in rats. (a–f) Representative photomicrographs of MAP2 immunostaining in sections from spinal cords of pre-SCI rats and damaged spinal cords of rats at 7 and 14 days after SCI ((a), (c), and (e): vehicle (DDW); (b), (d), and (f): RGE (350 mg/kg/day); (a) and (b): pre-SCI; (c) and (d): 7 days after SCI; (e) and (f): 14 days after SCI). Scale bar = 200 μm. Cracks are observed in the white matter in and around the central canal ((c), (d), and (e), arrows). (g) Quantification of MAP2-positive cells in the ventral horn of injured spinal cord. There was a significant increase in neural density at day 14 in RGE-treated rats ( in each group). All values are presented as mean ± SD. indicates significantly higher values than vehicle-treated control.