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Evidence-Based Complementary and Alternative Medicine
Volume 2017, Article ID 1323297, 6 pages
Research Article

Efficacy of Combined XingZhi-YiNao Granules and Hyperbaric Oxygen Therapy for Cognition and Motor Dysfunction in Patients with Delayed Encephalopathy after Acute Carbon Monoxide Poisoning

1Department of Integration of Chinese and Western Medicine, The Affiliated Yantai Yuhuangding Hospital of Qingdao University, Yantai, Shandong 264000, China
2Eye Institute of Shandong University of Traditional Chinese Medicine, Jinan, Shandong 250002, China
3Emergency Center, The Affiliated Yantai Yuhuangding Hospital of Qingdao University, Yantai, Shandong 264000, China
4Department of Clinical Medicine, Qingdao University Medical College, Qingdao, Shandong 266003, China

Correspondence should be addressed to Li Qin; moc.361@510107niqil, Bi Mingjun; moc.361@00nujgnimib, and Zou Yong; moc.anis@yzpmty

Received 8 July 2017; Accepted 26 October 2017; Published 26 November 2017

Academic Editor: Caigan Du

Copyright © 2017 Li Qin et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Purpose. To investigate the efficacy of XingZhi-YiNao (XZYN) granules and hyperbaric oxygenation (HBO) for cognition and motor dysfunction in patients with delayed encephalopathy after acute carbon monoxide poisoning (DEACMP). Methods. Eighty-nine patients with DEACMP were randomly divided into control group (), HBO group (), and XZYN group (). All patients received conventional treatment. HBO group received HBO therapy once daily. XZYN group received extra XZYN granules plus HBO treatment. The related indexes including activity of daily living (ADL) scale, Montreal cognitive assessment (MoCA) scale, and mini mental state examination (MMSE) scale were measured. Cerebral white matter injury, age related white matter changes (ARWMC) scale, and the amplitude and latency of P300 were assessed. Results. Compared with control group, the neurological function scores of ADL, MoCA, and MMSE in HBO and XZYN groups were significantly improved, the impairment degree of brain white matter and cognition function were obviously alleviated, the latencies of P300 were significantly shortened, and the amplitudes of P300 were evidently increased (). Treatment efficacy of XZYN group was superior to that of HBO group (). Conclusion. Combined XZYN granules and HBO can significantly improve cognition and motor functions in patients with DEACMP.