Table of Contents Author Guidelines Submit a Manuscript
Evidence-Based Complementary and Alternative Medicine
Volume 2017 (2017), Article ID 1960517, 13 pages
https://doi.org/10.1155/2017/1960517
Research Article

Antiarthritic Activity of Qi-Wu Rheumatism Granule (a Chinese Herbal Compound) on Complete Freund’s Adjuvant-Induced Arthritis in Rats

1Department of Immunology, School of Preclinical Medicine, Xinjiang Medical University, Urumqi 830011, China
2Department of Biology, School of Preclinical Medicine, Xinjiang Medical University, Urumqi 830011, China
3Center of Functional Experiment, School of Preclinical Medicine, Xinjiang Medical University, Urumqi 830011, China
4Department of Pharmacology, School of Preclinical Medicine, Xinjiang Medical University, Urumqi 830011, China

Correspondence should be addressed to Lu-feng Cheng

Received 27 June 2017; Revised 12 September 2017; Accepted 28 September 2017; Published 7 November 2017

Academic Editor: Young-Su Yi

Copyright © 2017 Qi Xu et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Objective. The aim was to study the therapeutic effects and mechanisms of QWRG on adjuvant-induced RA in rats. Methods. The RA rat models were manipulated and subsequently divided into five experimental groups: AIA, DEX, and QWRG groups. The paw volume, body weight, arthritic score, and mechanical nociceptive threshold were assessed. The serum levels of the RF, MDA, ALP, AST, ALT, IL-1β, IL-2, IL-16, and TNF-α were measured. The proliferative capacity of lymphocytes was evaluated, and the synovial tissue was histopathologically examined. Results. The paw swelling and arthritic scores were relieved, and the variation of relative body weight and mechanical nociceptive threshold had improved in the AIA rats. The serum levels of RF, MDA, ALP, AST, and ALT were alleviated, and the inflammation and cartilage damage were effectively attenuated in the AIA rats. Simultaneously, the inflammation of the synovial cavity was alleviated, and the grading of synovitis reduced by inhibiting the expressions of IL-1β, TNF-α, and IL-16 in the serum and synovium tissue. Conclusion. Our results suggested that the antiarthritic properties of QWRG may be due to immunodepression and downregulation of inflammatory cytokines, which may be a potential candidate for the treatment of RA.