|
| Author | Indication | Male | Age | Case number | Intervention methods | Outcome measurement | Courses |
| Test group | Controls | Test group | Controls | Test group | Controls |
|
| Tian [15] | Cerebral arterial thrombosis | 21/19 | 56.45 ± 9.03 | 55.40 ± 10.48 | 30 | 30 | 4 pills of YD capsule, tid + conventional treatment | Conventional therapy (flunarizine, nimodipine, hydroxyethylrutin, etc.) | ①②③⑤ | 45 d |
| Zhang [16] | Cerebral arterial thrombosis | 45/42 | 39~81 | 37~84 | 65 | 65 | 4 pills of YD capsule, tid + conventional treatment | Conventional antipressure & cerebral protection therapy | ①② | 28 d |
| Kang [17] | Cerebral infarction | 24/25 | 45~75 | 47~75 | 45 | 45 | 4 pills of YD capsule, tid + conventional treatment | Conventional therapy (atorvastatin, aspirin) | ①④ | 84 d |
| T. Li and K.-T. Li [18] | Cerebral infarction | 31/29 | 37~75 | 35~75 | 56 | 52 | 4 pills of YD capsule, tid + conventional treatment | Conventional therapy (aspirin) | ①②③ | 14 d |
| Ma et al. [19] | Cerebral infarction | 18/18 | 55~72 | 58~74 | 30 | 28 | 4 pills of YD capsule, tid + conventional treatment | Conventional antiplatelet & antilipid therapy | ①②③ | 28 d |
| Shao et al. [20] | Cerebral infarction | 25/22 | 48~78 | 45~75 | 40 | 40 | 4 pills of YD capsule, tid + conventional treatment | Conventional antiplatelet & antilipid therapy | ①②⑤ | 56 d |
| Wu [21] | Cerebral infarction | 49/22 | NA | NA | 80 | 40 | 4 pills of YD capsule, tid + conventional treatment | Conventional therapy (mannitol, etc.) | ①③④ | 28 d |
| Chen [22] | Cerebral infarction | 25/22 | 48~78 | 47~75 | 50 | 48 | 4 pills of YD capsule, tid + conventional treatment | Conventional antiplatelet & antilipid therapy | ①②⑤ | 56 d |
| Yang [23] | Cerebral arterial thrombosis | NA | NA | NA | 40 | 40 | 4 pills of YD capsule, tid + conventional treatment | Conventional therapy (mannitol, etc.) | ①②⑤ | 21 d |
| Wang [24] | Cerebral arterial thrombosis | NA | NA | NA | 42 | 42 | 4 pills of YD capsule, tid + conventional treatment | Conventional therapy | ① | NA |
| Luo [25] | Cerebral arterial thrombosis | 24/40 | 55~85 | NA | 40 | 40 | 4 pills of YD capsule, tid + conventional treatment | Conventional therapy (nimodipine, etc.) | ①②⑤ | 30 d |
| Wang and Li [26] | Cerebral arterial thrombosis | 30/28 | 61.8 ± 3.2 | 61.3 ± 3.4 | 50 | 50 | 4 pills of YD capsule, tid + conventional treatment | Conventional therapy | ① | NA |
| Yang [27] | Cerebral infarction | 20/19 | 44~77 | 41~74 | 31 | 31 | 4 pills of YD capsule, tid + conventional treatment | Conventional therapy (aspirin, etc.) | ①③④ | 30 d |
| Lv and Liu [28] | Cerebral apoplexy | 17/15 | 61.4 ± 5.3 | 62.7 ± 4.5 | 30 | 28 | 4 pills of YD capsule, tid + conventional treatment | Conventional therapy (nimodipine, etc.) | ①②③④⑤ | 30 d |
| Meng [29] | Cerebral infarction | 17/19 | 48~80 | 50~83 | 35 | 35 | 4 pills of YD capsule, tid + conventional treatment | Conventional therapy | ①③ | 14 d |
| Wang et al. [30] | Cerebral infarction | 25/26 | 62 ± 3.8 | 58 ± 4.3 | 55 | 53 | 4 pills of YD capsule, tid + conventional treatment | Conventional therapy (aspirin, etc.) | ①③ | 90 d |
| Su et al. [31] | Angina pectoris, CHD | 34/32 | 60~80 | 60~79 | 40 | 40 | 4 pills of YD capsule, tid + conventional treatment | Conventional therapy (nitrates, aspirin, etc.) | ①⑥ | 84 d |
| Yang [32] | Angina pectoris, CHD | 28/22 | 49~73 | 47~69 | 47 | 46 | 4 pills of YD capsule, tid + conventional treatment | Conventional therapy (nitrates, aspirin, etc.) | ①⑥ | 30 d |
| Yu et al. [33] | Angina pectoris | NA | NA | NA | 50 | 30 | 4 pills of YD capsule, tid + conventional treatment | Conventional therapy (nitrates, aspirin, etc.) | ①④⑥⑦ | 28 d |
| Xiao [34] | Angina pectoris, CHD | 22/22 | 60~74 | 60~71 | 36 | 35 | 4 pills of YD capsule, tid + conventional treatment | Conventional therapy (nitrates, β-receptor blocker, aspirin, etc.) | ①⑥ | 56 d |
| Li [35] | Angina pectoris, CHD | NA | NA | NA | 45 | 45 | 4 pills of YD capsule, tid + conventional treatment | Conventional therapy (aspirin, calcium antagonist, etc.) | ①④⑥⑦ | 56 d |
| Zhao [36] | Angina pectoris, CHD | 18/16 | 45~84 | 44~79 | 30 | 30 | 4 pills of YD capsule, tid + conventional treatment | Aspirin and nitric acid | ①⑥ | 30 d |
| Hu and Xiao [37] | Angina pectoris | 108/112 | 38~91 | 40~89 | 201 | 201 | 4 pills of YD capsule, tid + conventional treatment | Conventional therapy (β-receptor blocker, aspirin, etc.) | ① | 90 d |
| Shang et al. [38] | CHD | 28/27 | 65.8 ± 6.1 | 67.1 ± 6.2 | 58 | 57 | 4 pills of YD capsule, tid + conventional treatment | Conventional therapy (nitrates, β-receptor blocker, aspirin, etc.) | ①④ | 56 d |
| Luo et al. [39] | Angina pectoris, CHD | 34/32 | 48~73 | 50~72 | 50 | 50 | 4 pills of YD capsule, tid + conventional treatment | Conventional therapy (β-receptor blocker, calcium antagonist, aspirin, etc.) | ①④⑥ | 56 d |
| He [40] | Angina pectoris, CHD | 17/18 | 43~79 | 45~78 | 30 | 30 | 4 pills of YD capsule, tid + conventional treatment | Conventional therapy (nitrates, aspirin, etc.) | ①⑦ | 30 d |
| Guo [41] | Angina pectoris | 18/16 | 81.0 ± 3.3 | 83.0 ± 4.4 | 32 | 32 | 4 pills of YD capsule, tid + conventional treatment | Conventional therapy (isosorbide mononitrate) | ①⑥ | 28 d |
| Jin and Song [42] | Angina pectoris, CHD | 32/20 | 69~78 | 48~79 | 41 | 25 | 4 pills of YD capsule, tid + conventional treatment | Conventional therapy (isosorbide mononitrate) | ①⑥ | 30 d |
| Li et al. [43] | Angina pectoris, CHD | 28/26 | 70~88 | 77~89 | 40 | 40 | 4 pills of YD capsule, tid + conventional treatment | Conventional therapy (isosorbide mononitrate) | ①⑥ | 30 d |
| Cai [44] | Angina pectoris, CHD | 17/18 | 43~79 | 45~78 | 30 | 30 | 4 pills of YD capsule, tid + conventional treatment | Conventional therapy (nitrates, aspirin, etc.) | ①⑥ | 30 d |
| Xing and Zhang [45] | Angina pectoris, CHD | 19/32 | 55.9 ± 13.2 | 56.5 ± 12.9 | 33 | 32 | 4 pills of YD capsule, tid + conventional treatment | Conventional therapy (nitrates, aspirin, etc.) | ①③⑥ | 42 d |
| Shen [46] | Angina pectoris, CHD | 31/21 | 45~80 | 43~78 | 34 | 32 | 4 pills of YD capsule, tid + conventional treatment | Conventional therapy (nitrates, aspirin, etc.) | ①③ | 28 d |
| Shen and Zhang [47] | Angina pectoris, CHD | 42/32 | 69~85 | 67~87 | 55 | 42 | 4 pills of YD capsule, tid + conventional treatment | Conventional therapy | ① | 84 d |
| Yuan et al. [48] | Angina pectoris, CHD | 22/23 | 29~70 | 31~70 | 30 | 30 | 4 pills of YD capsule, tid + conventional treatment | Conventional therapy | ①⑥ | 56 d |
| Zhou et al. [49] | Angina pectoris | 14/19 | 42~72 | 40~73 | 30 | 30 | 4 pills of YD capsule, tid + conventional treatment | Conventional therapy | ①③⑥ | 56 d |
| Gu [50] | Angina pectoris | 15/17 | 55.6 ± 3.4 | 57.3 ± 3.6 | 22 | 22 | 4 pills of YD capsule, tid + conventional treatment | Conventional therapy | ①⑥ | 56 d |
| Gao et al. [51] | Angina pectoris | 22/23 | 62~74 | 60~71 | 42 | 43 | 4 pills of YD capsule, tid + conventional treatment | Conventional therapy (nitrates, β-receptor blocker, hydroxyethylrutin, aspirin, etc.) | ①⑥ | 56 d |
| Li [52] | Angina pectoris, CHD | 37/35 | 53~80 | 52~77 | 55 | 55 | 4 pills of YD capsule, tid + conventional treatment | Conventional therapy (nitrates, calcium antagonist, aspirin, etc.) | ①⑥ | 56 d |
| Zhou et al. [53] | Angina pectoris, CHD | 80/78 | 50~82 | 42~78 | 142 | 140 | 4 pills of YD capsule, tid + conventional treatment | Conventional therapy (isosorbide mononitrate, aspirin, etc.) | ①④⑥⑦ | 56 d |
| Qiao et al. [54] | Angina pectoris | 50/42 | 56.8 ± 6.8 | 55.2 ± 5.6 | 90 | 90 | 4 pills of YD capsule, tid + conventional treatment | Conventional therapy | ①④ | 180 d |
| Xu et al. [55] | Angina pectoris, CHD | NA | NA | NA | 30 | 30 | 4 pills of YD capsule, tid + conventional treatment | Conventional therapy (isosorbide mononitrate, aspirin, etc.) | ①⑥ | 56 d |
| Yan et al. [56] | Angina pectoris, CHD | 38/36 | 48~69 | 52~71 | 50 | 50 | 4 pills of YD capsule, tid + conventional treatment | Conventional therapy (nitrates, β-receptor blocker, calcium antagonist, aspirin, etc.) | ①⑥ | 84 d |
| Du [57] | CHD | 45/42 | 41~85 | 44~84 | 75 | 75 | 4 pills of YD capsule, tid + conventional treatment | Conventional therapy (nitrates, calcium antagonist, etc.) | ①④ | 56 d |
| Du [58] | Angina pectoris, CHD | 27/24 | 45~84 | 44~79 | 50 | 50 | 4 pills of YD capsule, tid + conventional treatment | Conventional therapy (nitrates, β-receptor blocker, calcium antagonist, hydroxyethylrutin, aspirin, etc.) | ①⑥ | 56 d |
| Zhang [59] | Angina pectoris, CHD | 16/17 | 52~78 | 56~83 | 30 | 30 | 4 pills of YD capsule, tid + conventional treatment | Conventional therapy | ①⑥ | 28 d |
| Lan et al. [60] | CHD | 108/112 | 60~93 | 60~96 | 200 | 200 | 4 pills of YD capsule, tid + conventional treatment | Conventional therapy (nitrates, β-receptor blocker, calcium antagonist, aspirin, etc.) | ①④⑥ | 60 d |
| Tuo and Shen [61] | Angina pectoris | NA | NA | NA | 24 | 23 | 4 pills of YD capsule, tid + conventional treatment | Conventional therapy | ①③ | 180 d |
| Huang et al. [62] | Angina pectoris, CHD | 51/49 | 52~77 | 51~79 | 90 | 90 | 4 pills of YD capsule, tid + conventional treatment | Conventional therapy | ①④⑥ | 56 d |
| Liu et al. [63] | Angina pectoris | 31/39 | 42~72 | 40~73 | 64 | 68 | 3 pills of YD capsule, tid + conventional treatment | Conventional therapy | ①③ | 56 d |
|
