Research Article
Icariin Prevents IL-1β-Induced Apoptosis in Human Nucleus Pulposus via the PI3K/AKT Pathway
Figure 6
As shown above, IL-1β could induce apoptosis-related protein changes. (a) Bax and cleaved caspase-3 are two important apoptosis-promoter proteins and Bcl-2 is an antiapoptosis protein. An increase of Bcl-2 and a decline of bax and cleaved caspase-3, when pretreated with icariin, showed a protective effect of icariin. (b) The bar graph comes from (a) ( versus control group, versus control group). When the PI3K/AKT pathway was blocked by LY294002, this protective effect was diminished.
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