Research Article

Roles of Nitric Oxide and Prostaglandins in the Sustained Antihypertensive Effects of Acanthospermum hispidum DC. on Ovariectomized Rats with Renovascular Hypertension

Figure 4

ESAH treatment reduces TBARS (a) and NT (b) levels and increases NO bioavailability (c). The serum samples were obtained after 28 days of treatment with vehicle, ESAH (30, 100, and 300 mg/kg), ENAL (15 mg/kg), or HCTZ (25 mg/kg). The results show the mean ± SEM (-7). Statistical analyses were performed by means of one-way analysis of variance (ANOVA) followed by Dunnett’s test.. when compared to 2K1C plus OVT-rats (C+). when compared to Sham-operated group. ENAL: enalapril; HCTZ: hydrochlorothiazide; NT: nitrosamine; Sham: placebo surgery; TBARS: thiobarbituric acid reactive substances.