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Evidence-Based Complementary and Alternative Medicine
Volume 2017, Article ID 2675631, 8 pages
Research Article

In Vitro Screening for Cytotoxic Activity of Herbal Extracts

Health Biotechnology Department, EBIOTEC, Bergondo, La Coruña, Spain

Correspondence should be addressed to Iván Carrera; moc.cetoibe@dulasaigoloncetoib

Received 4 January 2017; Revised 16 February 2017; Accepted 6 March 2017; Published 13 March 2017

Academic Editor: Valeria Sulsen

Copyright © 2017 Valter R. M. Lombardi et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Experimental studies have shown that a variety of chemopreventive plant components affect tumor initiation, promotion, and progression and the main difference, between botanical medicines and synthetic drugs, resides in the presence of complex metabolite mixtures shown by botanical medicine which in turn exert their action on different levels and via different mechanisms. In the present study, we performed an in vitro screening of ethanol extracts from commercial plants in order to investigate potential antitumor activity against human tumor cell lines. Experimental results obtained through a variety of methods and techniques indicated that extracts of I. verum, G. glabra, R. Frangula, and L. usitatissimum present significant reduction in in vitro tumor cell proliferation, suggesting these extracts as possible chemotherapeutical adjuvants for different cancer treatments.