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Evidence-Based Complementary and Alternative Medicine
Volume 2017, Article ID 2695903, 9 pages
https://doi.org/10.1155/2017/2695903
Research Article

Saikosaponin A Alleviates Symptoms of Attention Deficit Hyperactivity Disorder through Downregulation of DAT and Enhancing BDNF Expression in Spontaneous Hypertensive Rats

1The First Clinical College, Nanjing University of Chinese Medicine, Nanjing, Jiangsu 210023, China
2Jiangsu Key Laboratory of Pediatric Respiratory Disease, Institute of Pediatrics, Nanjing University of Chinese Medicine, Nanjing, Jiangsu 210023, China
3Nanjing General Hospital of Nanjing Military Command, Nanjing, Jiangsu 210002, China
4Affiliated Hospital of Nanjing University of Chinese Medicine, Nanjing, Jiangsu 210023, China

Correspondence should be addressed to Han Xinmin; moc.361@jn1mxh

Received 13 September 2016; Accepted 18 December 2016; Published 15 February 2017

Academic Editor: Jeng-Ren Duann

Copyright © 2017 Sun Jichao et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. J. Biederman and S. V. Faraone, “Attention-deficit hyperactivity disorder,” The Lancet, vol. 366, no. 9481, pp. 237–248, 2005. View at Publisher · View at Google Scholar · View at Scopus
  2. G. Polanczyk, M. S. de Lima, B. L. Horta, J. Biederman, and L. A. Rohde, “The worldwide prevalence of ADHD: a systematic review and metaregression analysis,” The American Journal of Psychiatry, vol. 164, no. 6, pp. 942–948, 2007. View at Publisher · View at Google Scholar · View at Scopus
  3. H. Caci and S. Paillé, “Attention-deficit/hyperactivity disorder in childhood/adolescence and impairments associated with daily life: French data from the European lifetime impairment survey,” Archives de Pediatrie, vol. 21, no. 12, pp. 1283–1292, 2014. View at Publisher · View at Google Scholar · View at Scopus
  4. J. Geissler and K.-P. Lesch, “A lifetime of attention-deficit/hyperactivity disorder: diagnostic challenges, treatment and neurobiological mechanisms,” Expert Review of Neurotherapeutics, vol. 11, no. 10, pp. 1467–1484, 2011. View at Publisher · View at Google Scholar · View at Scopus
  5. A. Thapar, M. Cooper, O. Eyre et al., “What have we learnt about the causes of ADHD?” Journal of Child Psychology and Psychiatry, vol. 54, no. 1, pp. 3–16, 2013. View at Google Scholar
  6. M. Rutter, “Achievements and challenges in the biology of environmental effects,” Proceedings of the National Academy of Sciences of the United States of America, vol. 109, supplement 2, pp. 17149–17153, 2012. View at Publisher · View at Google Scholar · View at Scopus
  7. S. V. Faraone, J. Biederman, and M. C. Monuteaux, “Toward guidelines for pedigree selection in genetic studies of attention deficit hyperactivity disorder,” Genetic Epidemiology, vol. 18, no. 1, pp. 1–16, 2000. View at Publisher · View at Google Scholar · View at Scopus
  8. M. A. Nikolas and S. A. Burt, “Genetic and environmental influences on ADHD symptom dimensions of inattention and hyperactivity: a meta-analysis,” Journal of Abnormal Psychology, vol. 119, no. 1, pp. 1–17, 2010. View at Publisher · View at Google Scholar · View at Scopus
  9. E. Stergiakouli, M. Hamshere, P. Holmans et al., “Investigating the contribution of common genetic variants to the risk and pathogenesis of ADHD,” The American Journal of Psychiatry, vol. 169, no. 2, pp. 186–194, 2012. View at Publisher · View at Google Scholar · View at Scopus
  10. J. M. Swanson, M. Kinsbourne, J. Nigg et al., “Etiologic subtypes of attention-deficit/hyperactivity disorder: brain imaging, molecular genetic and environmental factors and the dopamine hypothesis,” Neuropsychology Review, vol. 17, no. 1, pp. 39–59, 2007. View at Publisher · View at Google Scholar · View at Scopus
  11. D. Li, P. C. Sham, M. J. Owen, and L. He, “Meta-analysis shows significant association between dopamine system genes and attention deficit hyperactivity disorder (ADHD),” Human Molecular Genetics, vol. 15, no. 14, pp. 2276–2284, 2006. View at Publisher · View at Google Scholar · View at Scopus
  12. C. L. German, M. G. Baladi, L. M. McFadden, G. R. Hanson, and A. E. Fleckenstein, “Regulation of the dopamine and vesicular monoamine transporters: pharmacological targets and implications for disease,” Pharmacological Reviews, vol. 67, no. 4, pp. 1005–1024, 2015. View at Publisher · View at Google Scholar · View at Scopus
  13. D. M. Omiatek, A. J. Bressler, A.-S. Cans, A. M. Andrews, M. L. Heien, and A. G. Ewing, “The real catecholamine content of secretory vesicles in the CNS revealed by electrochemical cytometry,” Scientific Reports, vol. 3, article 1447, 2013. View at Publisher · View at Google Scholar · View at Scopus
  14. H. Kim, H.-I. Heo, D.-H. Kim et al., “Treadmill exercise and methylphenidate ameliorate symptoms of attention deficit/hyperactivity disorder through enhancing dopamine synthesis and brain-derived neurotrophic factor expression in spontaneous hypertensive rats,” Neuroscience Letters, vol. 504, no. 1, pp. 35–39, 2011. View at Publisher · View at Google Scholar · View at Scopus
  15. T. Kishi, Y. Hirooka, T. Nagayama et al., “Calorie restriction improves cognitive decline via up-regulation of brain-derived neurotrophic factor: tropomyosin-related kinase B in hippocampus of obesity-induced hypertensive rats,” International Heart Journal, vol. 56, no. 1, pp. 110–115, 2015. View at Publisher · View at Google Scholar · View at Scopus
  16. N. Easton, C. Steward, F. Marshall, K. Fone, and C. Marsden, “Effects of amphetamine isomers, methylphenidate and atomoxetine on synaptosomal and synaptic vesicle accumulation and release of dopamine and noradrenaline in vitro in the rat brain,” Neuropharmacology, vol. 52, no. 2, pp. 405–414, 2007. View at Publisher · View at Google Scholar · View at Scopus
  17. K. Koda, Y. Ago, Y. Cong, Y. Kita, K. Takuma, and T. Matsuda, “Effects of acute and chronic administration of atomoxetine and methylphenidate on extracellular levels of noradrenaline, dopamine and serotonin in the prefrontal cortex and striatum of mice,” Journal of Neurochemistry, vol. 114, no. 1, pp. 259–270, 2010. View at Publisher · View at Google Scholar · View at Scopus
  18. M. Ono, A. Yoshida, Y. Ito, and T. Nohara, “Phenethyl alcohol glycosides and isopentenol glycoside from fruit of Bupleurum falcatum,” Phytochemistry, vol. 51, no. 6, pp. 819–823, 1999. View at Publisher · View at Google Scholar · View at Scopus
  19. P. Bermejo Benito, M. J. Abad Martínez, A. M. Silván Sen et al., “In vivo and in vitro antiinflammatory activity of saikosaponins,” Life Sciences, vol. 63, no. 13, pp. 1147–1156, 1998. View at Publisher · View at Google Scholar · View at Scopus
  20. Y.-H. Yu, W. Xie, Y. Bao, H.-M. Li, S.-J. Hu, and J.-L. Xing, “Saikosaponin a mediates the anticonvulsant properties in the HNC models of AE and SE by inhibiting NMDA receptor current and persistent sodium current,” PLOS ONE, vol. 7, no. 11, Article ID e50694, 2012. View at Publisher · View at Google Scholar · View at Scopus
  21. X. Zhou, H. Cheng, D. Xu et al., “Attenuation of neuropathic pain by saikosaponin a in a rat model of chronic constriction injury,” Neurochemical Research, vol. 39, no. 11, pp. 2136–2142, 2014. View at Publisher · View at Google Scholar · View at Scopus
  22. W. H. Park, S. Kang, Y. Piao et al., “Ethanol extract of Bupleurum falcatum and saikosaponins inhibit neuroinflammation via inhibition of NF-κB,” Journal of Ethnopharmacology, vol. 174, no. 4, pp. 37–44, 2015. View at Publisher · View at Google Scholar · View at Scopus
  23. T. H. Lee, S. H. Park, M.-H. You, J.-H. Lim, S.-H. Min, and B. M. Kim, “A potential therapeutic effect of saikosaponin C as a novel dual-target anti-Alzheimer agent,” Journal of Neurochemistry, vol. 136, no. 6, pp. 1232–1245, 2016. View at Publisher · View at Google Scholar · View at Scopus
  24. S. S. Somkuwar, K. M. Kantak, M. T. Bardo, and L. P. Dwoskin, “Adolescent methylphenidate treatment differentially alters adult impulsivity and hyperactivity in the Spontaneously Hypertensive Rat model of ADHD,” Pharmacology Biochemistry and Behavior, vol. 141, pp. 66–77, 2016. View at Publisher · View at Google Scholar · View at Scopus
  25. C. D. Chambers, M. A. Bellgrove, M. G. Stokes et al., “Executive “brake failure” following deactivation of human frontal lobe,” Journal of Cognitive Neuroscience, vol. 18, no. 3, pp. 444–455, 2006. View at Publisher · View at Google Scholar · View at Scopus
  26. T. Sagvolden, “Behavioral validation of the spontaneously hypertensive rat (SHR) as an animal model of attention-deficit/hyperactivity disorder (AD/HD),” Neuroscience and Biobehavioral Reviews, vol. 24, no. 1, pp. 31–39, 2000. View at Publisher · View at Google Scholar · View at Scopus
  27. J. W. Dalley, R. N. Cardinal, and T. W. Robbins, “Prefrontal executive and cognitive functions in rodents: neural and neurochemical substrates,” Neuroscience and Biobehavioral Reviews, vol. 28, no. 7, pp. 771–784, 2004. View at Publisher · View at Google Scholar · View at Scopus
  28. P. Shaw, K. Eckstrand, W. Sharp et al., “Attention-deficit/hyperactivity disorder is characterized by a delay in cortical maturation,” Proceedings of the National Academy of Sciences of the United States of America, vol. 104, no. 49, pp. 19649–19654, 2007. View at Publisher · View at Google Scholar · View at Scopus
  29. A. F. T. Arnsten, “Fundamentals of attention-deficit/hyperactivity disorder: circuits and pathways,” Journal of Clinical Psychiatry, vol. 67, supplement 8, pp. 7–12, 2006. View at Publisher · View at Google Scholar · View at Scopus
  30. S. Cortese, C. Kelly, C. Chabernaud et al., “Toward systems neuroscience of ADHD: a meta-analysis of 55 fMRI sudies,” American Journal of Psychiatry, vol. 169, no. 10, pp. 1038–1055, 2012. View at Publisher · View at Google Scholar · View at Scopus
  31. A. F. T. Arnsten, “Toward a new understanding of attention-deficit hyperactivity disorder pathophysiology: an important role for prefrontal cortex dysfunction,” CNS Drugs, vol. 23, S1, pp. 33–41, 2009. View at Publisher · View at Google Scholar · View at Scopus
  32. C. Salaün, D. J. James, J. Greaves, and L. H. Chamberlain, “Plasma membrane targeting of exocytic SNARE proteins,” Biochimica et Biophysica Acta, vol. 1693, no. 2, pp. 81–89, 2004. View at Publisher · View at Google Scholar · View at Scopus
  33. A. Amiri, G. Torabi Parizi, M. Kousha et al., “Changes in plasma Brain-derived neurotrophic factor (BDNF) levels induced by methylphenidate in children with Attention deficit-hyperactivity disorder (ADHD),” Progress in Neuro-Psychopharmacology and Biological Psychiatry, vol. 47, no. 2, pp. 20–24, 2013. View at Publisher · View at Google Scholar · View at Scopus
  34. G. Y. Su, J. Y. Yang, F. Wang et al., “Antidepressant-like effects of Xiaochaihutang in a rat model of chronic unpredictable mild stress,” Journal of Ethnopharmacology, vol. 152, no. 1, pp. 217–226, 2014. View at Publisher · View at Google Scholar · View at Scopus