Research Article
Syndrome Differentiation of IgA Nephropathy Based on Clinicopathological Parameters: A Decision Tree Model
Table 5
Comparison of demographic and clinicopathological parameters between training and validation datasets.
| | | Training dataset () | Validation dataset () | value |
| | Age (years) | 32 (27–42) | 31 (25–42) | 0.899 | | Female, (%) | 196 (53.0) | 47 (50.0) | 0.606 | | Disease course (months) | 6 (2–23) | 9 (1–21) | 0.946 | | Inducement, (%) | | | Infection | 41 (11.1) | 16 (17.0) | 0.089 | | Fatigue | 13 (3.5) | 3 (3.2) | | Pregnancy | 25 (6.8) | 1 (1.1) | | No obvious inducement | 291 (78.6) | 74 (78.7) | | Systolic BP (mmHg) | 120 (110–132) | 127 (117–143) | <0.001 | | Diastolic BP (mmHg) | 80 (70–86) | 84 (75–93) | 0.001 | | MAP (mmHg) | 93 (86–101) | 98 (90–107) | <0.001 | | Hypertension, (%) | 136 (36.8) | 39 (41.5) | 0.285 | | Macroscopic hematuria, (%) | 66 (17.8) | 9 (9.6) | 0.052 | | U-RBC (/μL) | 45 (15–136) | 40 (13–172) | 0.798 | | Hemoglobin (g/L) | 128.2 ± 20.1 | 128.2 ± 20.1 | 0.693 | | Proteinuria (g/day) | 1.0 (0.5–2.2) | 1.0 (0.5–2.4) | 0.764 | | Uric acid (μmol/L) | 340 (274–429) | 410 (328–519) | <0.001 | | Serum albumin (g/L) | 40.3 (35.8–43.8) | 39.4 (35.3–42.9) | 0.238 | | Serum creatinine (μmol/L) | 79 (59–108) | 96 (72–151) | <0.001 | | eGFR (mL/min/1.73 m2) | 97.2 (67.2–120.5) | 78.8 (50.5–109.3) | <0.001 | | eGFR (mL/min/1.73 m2) | | | <15 | 6 (1.6) | 5 (5.3) | 0.001 | | >15, ≤30 | 15 (4.1) | 9 (9.6) | | >30, ≤60 | 53 (14.3) | 20 (21.3) | | >60, ≤90 | 94 (25.4) | 22 (23.4) | | >90 | 202 (54.6) | 38 (40.4) | | Serum IgA (g/L) | 2.85 (2.25–3.58) | 2.99 (2.23–3.57) | 0.736 | | Serum C3 (mg/L) | 0.98 (0.87–1.11) | 1.05 (0.87–1.20) | 0.045 | | Oxford MEST scores | | | M1, (%) | 361 (97.6) | 79 (86.8) | <0.001 | | E1, (%) | 54 (14.6) | 11 (12.1) | 0.538 | | S1, (%) | 185 (50.0) | 55 (60.4) | 0.074 | | T1, (%) | 193 (52.2) | 23 (25.3) | <0.001 | | T2, (%) | 68 (18.4) | 16 (17.6) |
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BP, blood pressure; MAP, mean arterial pressure; U-RBC, urinary red blood cell; eGFR, estimated glomerular filtration rate.
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