Preventive Effect and Safety of a Follicle Stimulating Hormone Inhibitory Formulation Containing a Mixture of Coicis Semen and Artemisia capillaris for Precocious Puberty: A Preliminary Experimental Study Using Female Rats

Table 2

Results of the blood component analysis of the control and test groups after 3 weeks of treatment. compared with the control value.

Index	Control	hEIF extract
		50 mg/kg	100 mg/kg	200 mg/kg
ALP (ng/mL)	123.54 ± 4.81	126.19 ± 3.35	124.79 ± 4.28	119.89 ± 2.18
Bone mineral density (g/cm^2)	0.090 ± 0.002	0.088 ± 0.003	0.088 ± 0.02	0.089 ± 0.003
Calcium (mg/dL)	2.33 ± 0.64	2.3 ± 0.59	2.38 ± 0.65	2.12 ± 0.50
Estradiol (pg/mL)	3.53 ± 0.21	3.54 ± 0.19	3.45 ± 0.35	3.12 ± 0.39
Glucose (mg/dL)	147.00 ± 24.24	167.80 ± 19.69	158.80 ± 19.40	175.80 ± 16.74
IGF-1 (ng/mL)	230.76 ± 12.12	197.91 ± 25.69	190.64 ± 20.17	185.82 ± 9.57
IGFBP-3 (ng/mL)	22.22 ± 1.05	19.65 ± 1.49	20.27 ± 0.45	21.1 ± 1.05
LH (mIU/mL)	292.33 ± 1.23	233.33 ± 1.63	293.4 ± 2.26	294.33 ± 2.13
Osteocalcin (pg/mL)	303.30 ± 4.79	306.90 ± 18.19	335.91 ± 14.46	326.83 ± 12.55
Total cholesterol (mg/dL)	62.50 ± 9.11	60.80 ± 7.26	56.60 ± 8.88	67.80 ± 10.83