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Evidence-Based Complementary and Alternative Medicine
Volume 2017, Article ID 2942830, 11 pages
https://doi.org/10.1155/2017/2942830
Research Article

DJC Suppresses Advanced Glycation End Products-Induced JAK-STAT Signaling and ROS in Mesangial Cells

1Anhui Province Key Laboratory of R&D of Chinese Medicine, School of Life Science, Anhui University, Hefei, Anhui 230601, China
2Department of Endocrinology, The First Affiliated Hospital of Anhui University of TCM, Hefei, Anhui 230031, China

Correspondence should be addressed to Zhaohui Fang; moc.621@7909hzgnaf

Received 21 October 2016; Revised 17 April 2017; Accepted 26 April 2017; Published 29 May 2017

Academic Editor: Isabel Andújar

Copyright © 2017 Min Sun et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. J. M. Bohlender, S. Franke, G. Stein, and G. Wolf, “Advanced glycation end products and the kidney,” The American Journal of Physiology—Renal Physiology, vol. 289, no. 4, pp. F645–F659, 2005. View at Publisher · View at Google Scholar · View at Scopus
  2. M. B. Marrero, A. K. Banes-Berceli, D. M. Stern, and D. C. Eaton, “Role of the JAK/STAT signaling pathway in diabetic nephropathy,” The American Journal of Physiology: Renal Physiology, vol. 290, no. 4, pp. F762–F768, 2006. View at Publisher · View at Google Scholar · View at Scopus
  3. M. C. Trengove and A. C. Ward, “SOCS proteins in development and disease,” American Journal of Clinical and Experimental Immunology, vol. 27, no. 1, p. 29, 2013. View at Google Scholar
  4. E. M. Linossi, J. J. Babon, D. J. Hilton, and S. E. Nicholson, “Suppression of cytokine signaling: the SOCS perspective,” Cytokine and Growth Factor Reviews, vol. 24, no. 3, pp. 241–248, 2013. View at Publisher · View at Google Scholar · View at Scopus
  5. Y. K. Chuah, R. Basir, H. Talib, T. H. Tie, and N. Nordin, “Receptor for advanced glycation end products and its involvement in inflammatory diseases,” International Journal of Inflammation, vol. 2013, Article ID 403460, 15 pages, 2013. View at Publisher · View at Google Scholar
  6. J.-S. Huang, Y. H. Lee, L. Y. Chuang, J. Y. Guh, and J. Y. Hwang, “Cinnamaldehyde and nitric oxide attenuate advanced glycation end products-induced the JAK/STAT signaling in human renal tubular cells,” Journal of Cellular Biochemistry, vol. 116, no. 6, pp. 1028–1038, 2015. View at Publisher · View at Google Scholar · View at Scopus
  7. F. Amiri, S. Shaw, X. Wang et al., “Angiotensin II activation of the JAK/STAT pathway in mesangial cells is altered by high glucose,” Kidney International, vol. 61, no. 5, pp. 1605–1616, 2002. View at Publisher · View at Google Scholar · View at Scopus
  8. A. M. Kay, C. L. Simpson, and J. A. Stewart, “The role of AGE/RAGE signaling in diabetes-mediated vascular calcification,” Journal of Diabetes Research, vol. 2016, Article ID 6809703, 8 pages, 2016. View at Publisher · View at Google Scholar · View at Scopus
  9. Z. H. Fang, “The effect of the plasma fibrinogen levels in type 2 Diabetes Mellitus with hyperlipemia treated by the Capsule of Danzhi Jiangtang,” Chinese Journal of Information on TCM, vol. 11, no. 10, pp. 852-853, 2004. View at Google Scholar
  10. Y. F. Niu, Z. H. Fang, J. Liu, and G. B. Shi, “The clinical efficacy of Danhzi Jiangtang Capsule on elderly patients with early diabetic nephropathy,” Modern Chinese Medicine, vol. 10, no. 5, pp. 36–38, 2008. View at Google Scholar
  11. Z. H. Fang, S. H. Cheng, and Q. Wu, “Effect of danzhi jiangtang capsule on NF-κB and urinary albumin excretion rate in early diabetic nephropathy patients,” World Science and Technology Modernization of TCM and Materia Medica, vol. 15, no. 5, pp. 891–895, 2013. View at Google Scholar
  12. S. S. Liu, Z. N. Li, C. Q. Xu, Y. Y. Xiong, and F. Zhang, “Effects of Danzhi Jiangtang Capsule on serum levels of Tumor Necrosis Factor Alpha and Chemokine (C-X-C Motif) ligand 5 in diabetic rats,” Journal of Anhui University of Chinese Medicine, vol. 33, no. 6, pp. 58–61, 2014. View at Google Scholar
  13. T. T. Bao, X. C. Yang, and G. Q. Chu, “Effects of Dangzhi Jiangtang Capsules on abdominal aortic ultrastructure, MCP-1 and resistin mRNA expression in diabetic rats,” Chinese Traditional Patent Medicine, vol. 37, no. 9, pp. 1888–1892, 2015. View at Google Scholar
  14. Z. N. Li, Y. Y. Xiong, L. Li, and Z. H. Fang, “Effects of Danzhi Jiangtang Capsule on CXCL9 and IL-8 in diabetic model rats,” Chinese Journal of Information on TCM, vol. 21, no. 12, pp. 45–47, 2014. View at Google Scholar
  15. Y. Y. Xiong, Z. N. Li, and S. S. Liu, “The influence of Danzhi Jiangtang Capsule on the expression of NF-κB in kidney tissue of diabetic rats,” Global Journal of Endocrinology and Metabolism Studies, vol. 34, no. 1, pp. 6–10, 2014. View at Google Scholar
  16. Chinese Pharmacopoeia Commission, The Pharmacopoeia of the People’s Republic of China, vol. 1, Chemical Industry Press, Beijing, China, 2005.
  17. Y. Q. Han, Y. Z. Wang, and L. Jiang, “Optimization of extracting process of Danzhi Jiangtang Capsule,” Chinese Journal of Information on Traditional Chinese Medicine, vol. 18, no. 2, pp. 55–57, 2011. View at Google Scholar
  18. Y. Z. Wang, L. Jiang, Y. Q. Han, D. Zuo, and L. Z. Xia, “UPLC fingerprint of Danzhi Jiangtang Capsule,” Clinical Journal of Traditional Chinese Medicine, vol. 24, no. 10, pp. 1009–1011, 2012. View at Google Scholar
  19. M. D. Oldfield, L. A. Bach, J. M. Forbes et al., “Advanced glycation end products cause epithelial-myofibroblast transdifferentiation via the receptor for advanced glycation end products (RAGE),” Journal of Clinical Investigation, vol. 108, no. 12, pp. 1853–1863, 2001. View at Publisher · View at Google Scholar · View at Scopus
  20. M. Sun, L. Huang, J. Zhu, W. Bu, J. Sun, and Z. Fang, “Screening nephroprotective compounds from cortex Moutan by mesangial cell extraction and UPLC,” Archives of Pharmacal Research, vol. 38, no. 6, pp. 1044–1053, 2015. View at Publisher · View at Google Scholar · View at Scopus
  21. A. R. Simon, U. Rai, B. L. Fanburg, and B. H. Cochran, “Activation of the JAK-STAT pathway by reactive oxygen species,” American Journal of Physiology, vol. 275, pp. C1640–C1652, 1998. View at Google Scholar
  22. M. Carballo, M. Conde, R. El Bekay et al., “Oxidative stress triggers STAT3 tyrosine phosphorylation and nuclear translocation in human lymphocytes,” Journal of Biological Chemistry, vol. 274, no. 25, pp. 17580–17586, 1999. View at Publisher · View at Google Scholar · View at Scopus
  23. G. Byfield, S. Budd, and M. E. Hartnett, “The role of supplemental oxygen and JAK/STAT signaling in intravitreous neovascularization in a ROP rat model,” Investigative Ophthalmology & Visual Science, vol. 50, no. 7, pp. 3360–3365, 2009. View at Publisher · View at Google Scholar · View at Scopus
  24. A. K. L. Banes, S. M. Shaw, A. Tawfik et al., “Activation of the JAK/STAT pathway in vascular smooth muscle by serotonin,” American Journal of Physiologym—Cell Physiology, vol. 288, no. 4, pp. C805–C812, 2005. View at Publisher · View at Google Scholar · View at Scopus
  25. S. Y. Kim, K.-A. Moon, H.-Y. Jo et al., “Anti-inflammatory effects of apocynin, an inhibitor of NADPH oxidase, in airway inflammation,” Immunology and Cell Biology, vol. 90, no. 4, pp. 441–448, 2012. View at Publisher · View at Google Scholar · View at Scopus
  26. C.-F. Chian, C.-H. Chiang, C. Yuan-Jung et al., “Apocynin attenuates lipopolysaccharide-induced lung injury in an isolated and perfused rat lung model,” Shock, vol. 38, no. 2, pp. 196–202, 2012. View at Publisher · View at Google Scholar · View at Scopus
  27. Y. Shi, Y. Zhang, C. Wang et al., “Suppressor of cytokine signaling-1 reduces high glucose-induced TGF-β1 and fibronectin synthesis in human mesangial cells,” FEBS Letters, vol. 582, no. 23-24, pp. 3484–3488, 2008. View at Publisher · View at Google Scholar · View at Scopus
  28. T. Naka, M. Narazaki, M. Hirata et al., “Structure and function of a new STAT-induced STAT inhibitor,” Nature, vol. 387, no. 6636, pp. 924–929, 1997. View at Publisher · View at Google Scholar · View at Scopus
  29. G. Ortiz-Muñoz, V. Lopez-Parra, O. Lopez-Franco et al., “Suppressors of cytokine signaling abrogate diabetic nephropathy,” Journal of the American Society of Nephrology, vol. 21, no. 5, pp. 763–772, 2010. View at Publisher · View at Google Scholar · View at Scopus
  30. L. A. O'Sullivan, C. Liongue, R. S. Lewis, S. E. M. Stephenson, and A. C. Ward, “Cytokine receptor signaling through the Jak-Stat-Socs pathway in disease,” Molecular Immunology, vol. 44, no. 10, pp. 2497–2506, 2007. View at Publisher · View at Google Scholar · View at Scopus
  31. A. Yoshimura, T. Naka, and M. Kubo, “SOCS proteins, cytokine signalling and immune regulation,” Nature Reviews Immunology, vol. 7, no. 6, pp. 454–465, 2007. View at Publisher · View at Google Scholar · View at Scopus
  32. S. Wormald, J.-G. Zhang, D. L. Krebs et al., “The comparative roles of suppressor of cytokine signaling-1 and -3 in the inhibition and desensitization of cytokine signaling,” Journal of Biological Chemistry, vol. 281, no. 16, pp. 11135–11143, 2006. View at Publisher · View at Google Scholar · View at Scopus
  33. D. L. Krebs and D. J. Hilton, “SOCS proteins: negative regulators of cytokine signaling,” STEM CELLS, vol. 19, no. 5, pp. 378–387, 2001. View at Publisher · View at Google Scholar · View at Scopus
  34. W. Kim, B. I. Hudson, B. Moser et al., “Receptor for advanced glycation end products and its ligands: a journey from the complications of diabetes to its pathogenesis,” Annals of the New York Academy of Sciences, vol. 1043, pp. 553–561, 2005. View at Publisher · View at Google Scholar · View at Scopus
  35. L. Park, K. G. Raman, K. J. Lee et al., “Suppression of accelerated diabetic atherosclerosis by the soluble receptor for advanced glycation endproducts,” Nature Medicine, vol. 4, no. 9, pp. 1025–1031, 1998. View at Publisher · View at Google Scholar · View at Scopus
  36. J. Huang, J. Guh, W. Hung et al., “Role of the Janus kinase (JAK)/signal transducters and activators of transcription (STAT) cascade in advanced glycation end-product-induced cellular mitogenesis in NRK-49F cells,” Biochemical Journal, vol. 342, no. 1, pp. 231–238, 1999. View at Publisher · View at Google Scholar · View at Scopus
  37. R. Gorina, C. Sanfeliu, A. Galitó, À. Messeguer, and A. M. Planas, “Exposure of glia to pro-oxidant agents revealed selective Stat1 activation by H2O2 and Jak2-independent antioxidant features of the Jak2 inhibitor AG490,” GLIA, vol. 55, no. 13, pp. 1313–1324, 2007. View at Publisher · View at Google Scholar · View at Scopus
  38. B. Schieffer, M. Luchtefeld, S. Braun, A. Hilfiker, D. Hilfiker-Kleiner, and H. Drexler, “Role of NAD(P)H oxidase in angiotensin II-induced JAK/STAT signaling and cytokine induction,” Circulation Research, vol. 87, no. 12, pp. 1195–1201, 2000. View at Publisher · View at Google Scholar · View at Scopus
  39. M. Ushio-Fukai, R. W. Alexander, M. Akers et al., “Reactive oxygen species mediate the activation of Akt/protein kinase B by angiotensin II in vascular smooth muscle cells,” The Journal of Biological Chemistry, vol. 274, no. 32, pp. 22699–22704, 1999. View at Publisher · View at Google Scholar · View at Scopus
  40. H. B. Lee, M. Yu, Y. Yang, Z. Jiang, and H. Ha, “Reactive oxygen species-regulated signaling pathways in diabetic nephropathy,” Journal of the American Society of Nephrology, vol. 14, no. 8, supplement 3, pp. S241–S245, 2003. View at Publisher · View at Google Scholar · View at Scopus
  41. X. Pan, X. Cao, N. Li et al., “Forsythin inhibits lipopolysaccharide-induced inflammation by suppressing JAK-STAT and p38 MAPK signalings and ROS production,” Inflammation Research, vol. 63, no. 7, pp. 597–608, 2014. View at Publisher · View at Google Scholar · View at Scopus
  42. J. J. Babon, L. N. Varghese, and N. A. Nicola, “Inhibition of IL-6 family cytokines by SOCS3,” Seminars in Immunology, vol. 26, no. 1, pp. 13–19, 2014. View at Publisher · View at Google Scholar · View at Scopus
  43. S. F. Ahmad, M. A. Ansari, K. M. Zoheir et al., “Regulation of TNF-α and NF-κB activation through the JAK/STAT signaling pathway downstream of histamine 4 receptor in a rat model of LPS-induced joint inflammation,” Immunobiology, vol. 220, no. 7, pp. 889–898, 2015. View at Publisher · View at Google Scholar · View at Scopus
  44. Y. Shi, C. Du, Y. Zhang et al., “Suppressor of cytokine signaling-1 ameliorates expression of MCP-1 in diabetic nephropathy,” American Journal of Nephrology, vol. 31, no. 5, pp. 380–388, 2010. View at Publisher · View at Google Scholar · View at Scopus