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Evidence-Based Complementary and Alternative Medicine
Volume 2017 (2017), Article ID 3014019, 10 pages
https://doi.org/10.1155/2017/3014019
Review Article

A Review of the Potential of Phytochemicals from Prunus africana (Hook f.) Kalkman Stem Bark for Chemoprevention and Chemotherapy of Prostate Cancer

1University of Science & Technology (UST), Korean Medicine Life Science, Daejeon 34054, Republic of Korea
2Korea Institute of Oriental Medicine (KIOM), Yuseongdae-ro, Yuseong-gu, Daejeon 34054, Republic of Korea
3Natural Chemotherapeutics Research Institute (NCRI), Ministry of Health, P.O. Box 4864, Kampala, Uganda
4Makerere University, P.O. Box 7062, Kampala, Uganda

Correspondence should be addressed to Youngmin Kang; rk.er.moik@gnakmy

Received 6 December 2016; Accepted 22 January 2017; Published 13 February 2017

Academic Editor: Dan Gincel

Copyright © 2017 Richard Komakech et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Prostate cancer remains one of the major causes of death worldwide. In view of the limited treatment options for patients with prostate cancer, preventive and treatment approaches based on natural compounds can play an integral role in tackling this disease. Recent evidence supports the beneficial effects of plant-derived phytochemicals as chemopreventive and chemotherapeutic agents for various cancers, including prostate cancer. Prunus africana has been used for generations in African traditional medicine to treat prostate cancer. This review examined the potential roles of the phytochemicals from P. africana, an endangered, sub-Saharan Africa plant in the chemoprevention and chemotherapy of prostate cancer. In vitro and in vivo studies have provided strong pharmacological evidence for antiprostate cancer activities of P. africana-derived phytochemicals. Through synergistic interactions between different effective phytochemicals, P. africana extracts have been shown to exhibit very strong antiandrogenic and antiangiogenic activities and have the ability to kill tumor cells via apoptotic pathways, prevent the proliferation of prostate cancer cells, and alter the signaling pathways required for the maintenance of prostate cancer cells. However, further preclinical and clinical studies ought to be done to advance and eventually use these promising phytochemicals for the prevention and chemotherapy of human prostate cancer.