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| Findings | Model | Treatment | Reference |
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| Jujube induced neurite outgrowth and neurofilament expression via cAMP-PKA-CREB signaling | Cultured PC12 cells; neuronal differentiation | Jujube extract compared with forskolin and control | [13] |
| The mature jujube possessed better effect in inducing neurofilament expression than that of the immature one | Cultured PC12 cells; neurofilament expression | Mature jujube extract compared with immature jujube extract | [19] |
| Jujube stimulated the expressions of neurotrophic factors and antioxidant enzymes | Cultured astrocytes; mRNA expression | Jujube at various concentrations (0–3 mg/ml) | [16] |
| Jujube protected neuronal cells against oxidation injury via activation of transcriptional activity of ARE | Cultured PC12 cells; tBHP induced oxidative stress | Jujube extract compared with Vit.C, , and negative control | [20] |
| Jujube protected neurons from ischemic damage | Ischemic damage in gerbil hippocampus | Oral administration of jujube extract for 10 days | [21] |
| Jujube increased pentobarbital-induced sleep time and reduce free movement on mice | Kunming mice, behavior and sleeping studies | Jujube at 8 g/kg was administered orally | [22] |
| Jujube promoted learning and memory in ovariectomized rat model | SD rats, Morris water maze test | Ovariectomized rats in 6 groups: jujube groups, positive, model, and sham surgery groups | [23] |
| Hydroalcoholic extract of jujube ameliorates seizures, oxidative stress, and cognitive impairment in epilepsy rat model | Rat, experimental seizure models | Hydroalcoholic extract of jujube (100, 250, 500, and 1000 mg/kg) was administered orally | [24] |
| Jujube had repairing effects on memory and behavioral disorders produced by NBM lesion in rats | Wistar male rats; Morris water maze test | Rats in 7 groups: normal, AD, AD/normal + jujubes at two doses, and sham | [25] |
| Methanolic jujube extract activated ChAT. Oleamide from jujube reversed the memory and/or cognitive impairment in mice model | Cultured MC-IXC cells, mice | Oleamide at 0.4–2.4 mM on activity; mice were treated with oleamide for 4 weeks | [26] |
| Jujube increased the cAMP content in plasma and hippocampus of animals | ICR male mice, cAMP level in hippocampus and serum | i.g. administration of jujube at 0.35 g/kg | [27] |
| A polypeptide Snakin-Z from jujube possessed cholinesterase inhibitory activity | Cholinesterase inhibitory activity | Snakin-Z at 1.5 mg/mL has 80% inhibitory activity | [28] |
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