Research Article

Compound Wumei Powder Inhibits the Invasion and Metastasis of Gastric Cancer via Cox-2/PGE2-PI3K/AKT/GSK3β/β-Catenin Signaling Pathway

Figure 5

CWP inhibits PI3K/AKT/GSK3β/β-catenin signaling pathway. (a) The expressions of p-AKT, AKT, p-GSK3β, GSK3β, and β-catenin were detected after treatment with IGF for 2 h and LY294002 for 24 hours. (b) The histogram shows the relative expression of protein in (a). (c) Observation of cell migration after the cells were treated with PI3K/AKT agonist IGF-1 and inhibitor LY294002. (d) The histogram shows the percentage of wound healing in SGC-7901 cells after administration. (e) Observation of cell invasion after the SGC-7901 cells were treated with IGF-1 and LY294002. (f) The histogram shows the number of SGC-7901 cells passing through the 8 μm pore size into the lower chamber. Data are expressed as the mean ± SD of three experiments ( < 0.05 compared with control group; < 0.01 compared with control group; NS means no significance).
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