Compound Wumei Powder Inhibits the Invasion and Metastasis of Gastric Cancer via Cox-2/PGE2-PI3K/AKT/GSK3β/β-Catenin Signaling Pathway

Figure 7

CWP can inhibit the invasion and metastasis of SGC-7901 via Cox-2/PGE2-PI3K/AKT/GSK3β/β-catenin signal axis. (a) Extracts from SGC-7901 cells of different groups treated with LY294002 and CWP were analyzed for the expressions of p-AKT/AKT, p-GSK3β/GSK3β, β-catenin, and nuclear β-catenin. (b) Extracts from SGC-7901 cells of different groups treated with PGE2 and LY294002 were analyzed for the expressions of p-AKT/AKT, p-GSK3β/GSK3β, β-catenin, and nuclear β-catenin. (c) The histogram shows the relative expression of each protein in (a). (d) The histogram shows the relative expression of each protein in (b). Data are expressed as the mean ± SD of three experiments ( < 0.01 compared with control group; NS means no significance).

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