Compound Wumei Powder Inhibits the Invasion and Metastasis of Gastric Cancer via Cox-2/PGE2-PI3K/AKT/GSK3β/β-Catenin Signaling Pathway

Figure 8

CWP can suppress the expressions of MMP-2, MMP-7, and MMP-14. (a)–(c) Immunohistochemistry assay was used to detect the expressions of MMP-2, MMP-7, and MMP-14 of (i) (control), (ii) (1 g/ml), (iii) (2 g/ml), and (iv) (4 g/ml) transplanted tumor; expression levels are higher in control group. (d) The histogram shows the mean density (average density) of MMP-2, MMP-7, and MMP-14. (e) Extracts from transplanted tumor were analyzed for the expressions of MMP-2, MMP-7, and MMP-14. (f) The histogram shows the expressions of MMP-2, MMP-7, and MMP-14 compared to the control group in vivo. (g) Extracts from SGC-7901 cells were analyzed for the expressions of MMP-2, MMP-7, and MMP-14; (h) The histogram shows the expressions of MMP-2, MMP-7, and MMP-14 compared to the control group in vitro ( < 0.05 compared with control group; < 0.01 compared with control group).

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