Effect of Tetramethylpyrazine on Atherosclerosis and SCAP/SREBP-1c Signaling Pathway in ApoE−/− Mice Fed with a High-Fat Diet
Tetramethylpyrazine (TMP) ameliorates blood lipids and atherosclerotic plaques. (a) TMP ameliorates the serum lipids disturbance in ApoE−/− mice fed with a high-fat diet. TC, total cholesterol; TG, triglycerides; HDL-C, high-density lipoprotein cholesterol; LDL-C, low-density lipoprotein cholesterol. versus the control group, . (b) Hematoxylin and eosin (HE) staining showing the pathological changes in the atherosclerotic plaque in the aorta of ApoE−/− mice after treatment with TMP. (1) ApoE−/− group; (2) ApoE−/− + Lipitor group; (3) ApoE−/− + TMP group. Scale bars = 200 μm; the black arrow indicates the atherosclerotic plaque in aorta. (c) Statistical analysis of the corrected area of atherosclerotic plaque of ApoE−/− mice after the TMP treatment. versus the control group; .