Effect of Tetramethylpyrazine on Atherosclerosis and SCAP/SREBP-1c Signaling Pathway in ApoE^−/− Mice Fed with a High-Fat Diet

Figure 2

Tetramethylpyrazine (TMP) ameliorates blood lipids and atherosclerotic plaques. (a) TMP ameliorates the serum lipids disturbance in ApoE^−/− mice fed with a high-fat diet. TC, total cholesterol; TG, triglycerides; HDL-C, high-density lipoprotein cholesterol; LDL-C, low-density lipoprotein cholesterol. versus the control group, . (b) Hematoxylin and eosin (HE) staining showing the pathological changes in the atherosclerotic plaque in the aorta of ApoE^−/− mice after treatment with TMP. (1) ApoE^−/− group; (2) ApoE^−/− + Lipitor group; (3) ApoE^−/− + TMP group. Scale bars = 200 μm; the black arrow indicates the atherosclerotic plaque in aorta. (c) Statistical analysis of the corrected area of atherosclerotic plaque of ApoE^−/− mice after the TMP treatment. versus the control group; .

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