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Evidence-Based Complementary and Alternative Medicine
Volume 2017, Article ID 3294586, 9 pages
https://doi.org/10.1155/2017/3294586
Research Article

Neuroprotective Effect of Fagopyrum dibotrys Extract against Alzheimer’s Disease

1Key Laboratory of Stem Cells and Regenerative Medicine, Institute of Molecular and Clinical Medicine, Kunming Medical University, Kunming, China
2Department of Pharmacy, First People’s Hospital of Qujin, Qujin, China
3School of Pharmacy and Medical Sciences, Sansom Institute, University of South Australia, Adelaide, SA, Australia

Correspondence should be addressed to Yue-Qin Zeng; moc.liamtoh@niqeuy_z

Received 20 November 2016; Revised 12 February 2017; Accepted 16 March 2017; Published 20 April 2017

Academic Editor: Evan P. Cherniack

Copyright © 2017 Chen Liang et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Accumulated evidence suggests that polyphenolic antioxidants present in herbs play important roles in prevention of AD; the molecular mechanisms behind neuroprotective actions rely on the phenols through different effects on the amyloid-aggregation pathway. Fagopyrum dibotrys is a traditional herbal medicine which contains high quantity phenols. In present study, we investigate the beneficial pharmacological actions of Fagopyrum dibotrys extract in the APP/PS1 transgenic mouse mode; meanwhile, effects of the FDE on the fibrillation and cytotoxicity of Aβ peptide were evaluated in vitro. After 9-month treatment, FDE exhibited multifunctional properties on Aβ-related pathologies, which cleaned Aβ deposits in the brain and decreased Aβ burden in the plasma, inhibited microhaemorrhage, and reduced reactive microglia in APP/PS1 transgenic mice and also promoted Aβ fibrils disaggregation and inhibited neurotoxicity induced by Aβ in SH-SY5Y cells. These results highlighted that FDE is an AD type pathology modulator with therapeutic potential against AD.