Research Article
Protective Effects of Wogonin against Alzheimer’s Disease by Inhibition of Amyloidogenic Pathway
Figure 6
Wogonin treatment attenuated the behavior on the novel object recognition task and Y-maze test in eight 3xTg-AD mice. 3xTg-AD mice were applied 10 mg/kg wogonin every other day from the 8th to the 24th week of age by intraperitoneal injection. (a) Novel object recognition (NOR) experiments were performed in the 23-week-old mice. The discrimination index was calculated as a percentage ratio of TB/(TA + TB) × 100. (a) Familiar object. (b) Novel object. (b) Spontaneous alternation behavior Y-maze tests were performed in the 8-, 16-, and 24-week-old mice. Alternation (%) = [(number of alternations)/(total arm entries − 2)] × 100. All of the values are shown as mean ± SEM, , , , and .
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