Protective Effects of Wogonin against Alzheimer’s Disease by Inhibition of Amyloidogenic Pathway

Figure 7

Wogonin decreased the levels of BACE1, p-Tau, and total Tau proteins in the cerebral tissue of three 3xTg-AD mice. Mice were given intraperitoneal injection with vehicle/wogonin (10 mg/kg) every other day from the 8th to the 24th week of age, and mice were sacrificed for western blot analysis in the 24th week of age. (a) The expression level of BACE1 in the cerebra of mice was measured using western blot analysis in the 24-week-old mice. (b) Quantitative analysis of the level of BACE1 was executed with ImageJ. (c) The cerebellar extracts of 3xTg-AD mice were immunostained against p-Tau and Tau protein in the 24-week-old mice. Relative intensity of p-Tau (d) and total Tau (e) was performed with ImageJ. Actin was used as a loading control. The results are shown as mean ± SEM, .

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