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Evidence-Based Complementary and Alternative Medicine
Volume 2017, Article ID 3607089, 11 pages
https://doi.org/10.1155/2017/3607089
Research Article

Central Administration of 1-Deoxynojirimycin Attenuates Hypothalamic Endoplasmic Reticulum Stress and Regulates Food Intake and Body Weight in Mice with High-Fat Diet-Induced Obesity

1Department of Anatomy, Graduate School of Dongguk University College of Medicine, 123 Dongdae-ro, Gyeongju-si 38066, Republic of Korea
2Graduate School of Integrated Bioindustry, Sejong University, 209 Neungdong-ro, Gwangjin-gu, Seoul 05006, Republic of Korea
3Department of Medical Zoology, Kyung Hee University, Seoul 02447, Republic of Korea
4Department of Biotechnology, Catholic University of Daegu, Gyeongsan-si, Gyeongsangbuk-do 38430, Republic of Korea
5Department of Biochemistry, Dongguk University College of Medicine, 123 Dongdae-ro, Gyeongju-si 38066, Republic of Korea

Correspondence should be addressed to Tae-Won Goo; rk.ca.kuggnod@wtoog

Received 23 January 2017; Revised 23 May 2017; Accepted 30 May 2017; Published 17 July 2017

Academic Editor: Teh Ley Kek

Copyright © 2017 Jongwan Kim et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

The α-glucosidase inhibitor, 1-deoxynojirimycin (DNJ), is widely used for its antiobesity and antidiabetic effects. Researchers have demonstrated that DNJ regulates body weight by increasing adiponectin levels, which affects energy intake and prevents diet-induced obesity. However, the mechanism by which centrally administered DNJ exerts anorexigenic effects has not been studied until now. We investigated the effect of DNJ in the hypothalamus of mice with high-fat diet-induced obesity. Results showed that intracerebroventricular (ICV) administration of DNJ reduced hypothalamic ER stress, which activated the leptin-induced Janus-activated kinase 2 (JAK2)/signal transducers and activators of transcription 3 (STAT3) signaling pathway to cause appetite suppression. We conclude that DNJ may reduce obesity by moderating feeding behavior and ER stress in the hypothalamic portion of the central nervous system (CNS).