Central Administration of 1-Deoxynojirimycin Attenuates Hypothalamic Endoplasmic Reticulum Stress and Regulates Food Intake and Body Weight in Mice with High-Fat Diet-Induced Obesity

Figure 5

Effect of central administration of DNJ on food intake and body weight in high-fat diet- (HFD-) fed mice. (a) The average cumulative body weight change and (b) average cumulative food intake were measured in HFD-fed mice after central administration of 50 μg/mL DNJ (1 μL) or vehicle (1 μL of distilled water; DW) during the experimental period. (c) Effects of central administration of DNJ on hypothalamic mRNA expression of neuropeptides. The results are the means ± SDs ( per group). values of < 0.05 indicate significant differences compared to those of the vehicle group (1 μL of DW). HFD/DNJ (+/−), central administration of vehicle of HFD-fed group. HFD/DNJ (+/+), central administration of DNJ of HFD-fed group.

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