Evidence-Based Complementary and Alternative Medicine / 2017 / Article / Fig 4

Research Article

Boi-ogi-to (TJ-20), a Kampo Formula, Suppresses the Inflammatory Bone Destruction and the Expression of Cytokines in the Synovia of Ankle Joints of Adjuvant Arthritic Rats

Figure 4

Influence of TJ-20 on the expression of cytokines in the synovia of ankle joint in AA rats. Photographs representing TNF-α-, IL-10-, IFN-γ-, and IL-4-positive mononuclear cells in the synovia of AA rats at week 2 and AA rats treated with TJ-20 according to schedule II (a), the percentages of TNF-α-positive (b), and IL-10-positive (c), IFN-γ-positive (d), and IL-4-positive (e) mononuclear cells in AA rats (closed circle) and AA rats treated with TJ-20 according to schedule II (open squares) were determined by immunohistochemistry. TJ-20 administered according to schedule II significantly suppressed the expression of TNF-α and IFN-γ and augmented the expression of IL-10 but did not augment the expression of IL-4. Asterisks indicate a statistically significant difference from AA rats (, ). Scale bar, 25 µm.

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