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Evidence-Based Complementary and Alternative Medicine
Volume 2017, Article ID 3801976, 9 pages
https://doi.org/10.1155/2017/3801976
Research Article

Naoxintong/PPAR Signaling Inhibits Cardiac Hypertrophy via Activation of Autophagy

1Institute of Life Sciences, Jiangsu University, Zhenjiang, Jiangsu 212013, China
2Department of Oncology, Affiliated Wujin People’s Hospital, Jiangsu University, Changzhou 212017, China
3Tianjin State Key Laboratory of Modern Chinese Medicine, Tianjin University of Traditional Chinese Medicine, 312 Anshanxi Road, Nankai District, Tianjin 300193, China
4Tianjin Key Laboratory of Traditional Chinese Medicine Pharmacology, Tianjin University of Traditional Chinese Medicine, 88 Yuquan Road, Nankai District, Tianjin 300193, China
5Key Laboratory of Pharmacology of Traditional Chinese Medical Formulae (Tianjin University of Traditional Chinese Medicine), Ministry of Education, Tianjin 300193, China

Correspondence should be addressed to Yongzhong Hou; nc.ude.sju.liam@zyuoh and Hong Wang; moc.621@sysgnohgnaw

Received 16 August 2016; Accepted 1 December 2016; Published 15 February 2017

Academic Editor: Kuzhuvelil B. Harikumar

Copyright © 2017 Shuping Yuan et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

As a traditional Chinese medicine, Naoxintong capsule (NXT) has been approved by China Food and Drug Administration (CFDA), which is used for cardiocerebrovascular disease treatment. Here we found that NXT extract significantly promoted H9c2 cardiomyocyte cell autophagy involved in increased autophagy-associated gene expression leading to inhibition of mTOR signaling. Moreover, NXT extract increased PPARγ protein expression and transcription activity of H9c2 cell. Consistent with this, in PPARγ gene silenced H9c2 cells, NXT had no effect on autophagy and mTOR signaling. Furthermore, NXT/PPARγ-mediated H9c2 autophagy led to inhibition of cardiomyocyte cell hypertrophy. These findings suggest that the extract of NXT inhibited H9c2 cardiomyocyte cell hypertrophy via PPARγ-mediated cell autophagy.