Dietary Supplementation of Hericium erinaceus Increases Mossy Fiber-CA3 Hippocampal Neurotransmission and Recognition Memory in Wild-Type Mice
Spontaneous synaptic excitatory currents (sEPSCs) recorded from CA3 pyramidal cells. (a) Left, schematic drawing of experimental set-up. gc: granule cell, CA3 pyramidal cell. Middle, patch-pipette in a CA3 neuron. Right, bath-application of 2 μM DCG-IV, a receptor agonist of Group II metabotropic glutamate that blocks glutamate release from mossy fibers terminals, selectively decreases mossy fiber response (see inset). ((b) and (c)) Excitatory currents (sEPSCs) and (d) frequency histogram of spontaneous activity recorded from CA3 pyramidal cells in dextrin treated mice (Dextrin, ) and in Hericium supplemented mice (Hericium erinaceus, ).