Evidence-Based Complementary and Alternative Medicine / 2017 / Article / Tab 1

Research Article

1H NMR-Based Metabonomic Study of Functional Dyspepsia in Stressed Rats Treated with Chinese Medicine Weikangning

Table 1

Quantitative comparison of metabolites identified in urine of model group (MS) and normal control group (NS).

MetabolitesChemical shiftIntegral in MS group (mean ± S.D.) × 10−2Integral in NS group (mean ± S.D.) × 10−2VIP

Leucine0.95 (t)10.112 ± 1.1558.732 ± 1.004 (↑)1.7790.004
Lactate1.335 (d)8.332 ± 0.9977.284 ± 0.951 (↑)1.8450.011
Alanine1.485 (d)6.328 ± 0.5395.582 ± 0.614 (↑)2.1350.002
Acetate1.93 (s)7.851 ± 2.28514.826 ± 27.119 (↓)1.7350.031
N-Acetylglutamate2.225 (t)10.518 ± 0.97812.481 ± 1.975 (↓)1.9810.013
Succinate2.41 (s)16.494 ± 5.22527.520 ± 12.593 (↓)1.9960.023
2-Oxoglutarate2.46 (t), 3.015 (t)48.701 ± 16.02972.679 ± 25.975 (↓)1.9660.005
Citrate2.565 (AB)21.411 ± 40.03473.047 ± 45.443 (↓)2.1660.004
Dimethylamine2.725 (s)64.191 ± 12.55548.890 ± 9.897 (↑)1.9510.002
Trimethylamine2.92 (s)3.671 ± 0.7184.701 ± 0.948 (↓)1.7530.003
Phenylacetylglycine3.68 (s)34.812 ± 6.58227.550 ± 3.781 (↑)1.7940.003
Hippurate3.965 (t), 7.71 (d), 7.83 (d)17.012 ± 2.05014.239 ± 1.772 (↑)1.8970.001
Allantoin5.39 (s)117.921 ± 32.11288.265 ± 30.123 (↑)1.6230.035
Cytidine6.07 (d)11.707 ± 2.5727.857 ± 1.949 (↑)1.9680.000
Tyrosine7.28 (s)7.227 ± 1.9315.411 ± 1.349 (↑)1.6180.009
Imidazole7.365 (t)25.161 ± 7.95915.153 ± 3.917 (↑)1.8880.001
Phenylalanine7.425 (t)9.045 ± 2.8915.604 ± 1.378 (↑)1.7820.001

The relative integrals of metabolites were determined by 1D 1H NMR analysis of urine. The values of the correlation number extracted from the correlation plots of OPLS-DA models of MS versus NS. The P values were obtained from Independent-Samples t-test or -test (shown with ). The P values were calculated by Mann–Whitney U test of nonparametric tests and the related integrals were presented in median ± IQR The arrows (↑/↓) denote higher/lower amounts relative to NS group.

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