Curcumin Induces p53-Null Hepatoma Cell Line Hep3B Apoptosis through the AKT-PTEN-FOXO4 Pathway

Figure 6

Effects of FOXO knockdown on curcumin induced Hep3B cell apoptosis. (a) FOXO1 knockdown; (b) FOXO3a knockdown; (c) FOXO4 knockdown; (d) caspase activities of FOXO4 knockdown experiments. -axis indicates propidium iodide (PI) intensities; -axis indicates caspase activities. The concentration of curcumin used in the experiments was 50 μM. The data are representative of triplicate experiments. CUR: curcumin. DMSO: dimethyl sulfoxide (solvent of curcumin).

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