In Vitro and In Vivo Studies on Quercus acuta Thunb. (Fagaceae) Extract: Active Constituents, Serum Uric Acid Suppression, and Xanthine Oxidase Inhibitory Activity

Figure 3

Hepatic xanthine oxidase (XO) activity after oral administration of saline in normal mice (normal) or after oral administration of saline (HU), allopurinol at a dose of 10 mg/kg (HU + ALP), or QALE at a dose of 50 (HU + QA50) or 250 mg/kg (HU + QA250) during 7 days prior to inducing hyperuricemia in mice. The rectangular bars and their error bars represent the means and standard deviations, respectively (); different from the normal group; different from the HU group (, ANOVA a posteriori Tukey’s multiple range test).