Investigating Potential Modes of Actions of Mimusops kummel Fruit Extract and Solvent Fractions for Their Antidiarrheal Activities in Mice
Table 3
Effects of 80% MeOH-E and solvent fractions of the fruits of M. kummel on castor oil induced enteropooling in mice.
Extracts
Dose administered
Mean volume of small intestinal content (gm)
% inhibition
Mean weight of small intestinal content (mL)
% inhibition
80% MeOH-E
Control1
0.85 ± 0.08
—
1.21 ± 0.10
—
100 mg/kg
0.63 ± 0.11
25.49
1.02 ± 0.17
15.63
200 mg/kg
0.52 ± 0.13
39.22
0.80 ± 0.02
33.61
400 mg/kg
0.42 ± 0.09
50.98
0.69 ± 0.01
43.02
3 mg/kg loperamide
0.45 ± 0.11
47.06
0.71 ± 0.01
41.36
Solvent fractions
Control2
0.87 ± 0.10
—
0.99 ± 0.10
—
Solvent fractions
CF100 mg/kg
0.75 ± 0.11
13.79
0.83 ± 0.07
16.16
CF200 mg/kg
0.57 ± 0.10
34.48
0.72 ± 0.10
27.30
CF400 mg/kg
0.50 ± 0.11
42.53
0.67 ± 0.10
32.33
Solvent fractions
n-BF100 mg/kg
0.63 ± 0.11
27.59
0.70 ± 0.10
29.31
n-BF200 mg/kg
0.58 ± 0.12
33.32
0.60 ± 0.02
39.40
n-BF400 mg/kg
0.37 ± 0.11
57.47
0.53 ± 0.08
46.45
Solvent fractions
AF100 mg/kg
0.53 ± 0.08
39.08
0.63 ± 0.02
36.35
AF200 mg/kg
0.42 ± 0.10
51.72
0.54 ± 0.02
45.50
AF400 mg/kg
0.38 ± 0.12
56.32
0.45 ± 0.03
54.53
Solvent fractions
3 mg/kg loperamide
0.30 ± 0.07
60.91
0.42 ± 0.04
57.58
Values are expressed as mean ± CI95 (n = 6); analysis was performed using one-way ANOVA followed by Tukey’s post hoc test; compared with control values; compared with loperamide; compared with 200 mg/kg; compared with 400 mg/kg; p < 0.05; 80% MeOH-E = 80% methanolic extract; CF = chloroform fraction; n-BF = n-butanol fraction; AF = aqueous fraction; CI95 = 95% confidence interval. Controls are 10 mL/kg distilled water (1for 80% MeOH-E) and 2% Tween 80 in distilled water (2for chloroform, n-butanol, and aqueous fractions).
