Research Article

Systems Pharmacological Approach of Pulsatillae Radix on Treating Crohn’s Disease

Table 2

Related targets of Pulsatillae Radix.

UniProt IDTargetGene name

Q92887Canalicular multispecific organic anion transporter 1ABCC2
P12821Angiotensin-converting enzymeACE
P22303AcetylcholinesteraseACHE
P24666Low molecular weight phosphotyrosine protein phosphataseACP1
P00326Alcohol dehydrogenase 1CADH1C
P35348Alpha-1A adrenergic receptorADRA1A
P35368Alpha-1B adrenergic receptorADRA1B
P25100Alpha-1D adrenergic receptorADRA1D
P08913Alpha-2A adrenergic receptorADRA2A
P18825Alpha-2C adrenergic receptorADRA2C
P08588Beta-1 adrenergic receptorADRB1
P07550Beta-2 adrenergic receptorADRB2
P15121Aldose reductaseAKR1B1
O60218Aldo-keto reductase family 1 member B10AKR1B10
P09917Arachidonate 5-lipoxygenaseALOX5
P09923Intestinal-type alkaline phosphataseALPI
P04746Pancreatic alpha-amylaseAMY2A
P10275Androgen receptorAR
P15336Cyclic AMP-dependent transcription factor ATF-2ATF2
P05023Sodium/potassium-transporting ATPase subunit alpha-1ATP1A1
P15291Beta-1,4-galactosyltransferase 1B4GALT1
Q07812Apoptosis regulator BAXBAX
P10415Apoptosis regulator Bcl-2BCL2
Q07817Bcl-2-like protein 1BCL2L1
O15392Baculoviral IAP repeat-containing protein 5BIRC5
O43570Carbonic anhydrase 12CA12
Q8N1Q1Carbonic anhydrase 13CA13
P00918Carbonic anhydrase IICA2
P22748Carbonic anhydrase IVCA4
P35218Carbonic anhydrase 5A, mitochondrialCA5A
Q16790Carbonic anhydrase VICA9
P62158CalmodulinCALM1
P29466Caspase-1CASP1
P42574Caspase-3CASP3
Q14790Caspase-8CASP8
P55211Caspase-9CASP9
P13500C-C motif chemokine 2CCL2
P20248Cyclin-A2CCNA2
P24385G1/S-specific cyclin-D1CCND1
P30279G1/S-specific cyclin-D2CCND2
P60033CD81 antigenCD81
P24941Cell division protein kinase 2CDK2
P11802Cell division protein kinase 4CDK4
Q00534Cell division protein kinase 6CDK6
P38936Cyclin-dependent kinase inhibitor 1CDKN1A
O14757Serine/threonine-protein kinase Chk1CHEK1
P11229Muscarinic acetylcholine receptor M1CHRM1
P08172Muscarinic acetylcholine receptor M2CHRM2
P20309Muscarinic acetylcholine receptor M3CHRM3
P08173Muscarinic acetylcholine receptor M4CHRM4
Q15822Neuronal acetylcholine receptor subunit alpha-2CHRNA2
P36544Neuronal acetylcholine receptor protein, alpha-7 chainCHRNA7
O15111NF-kappa-B inhibitor alphaCHUK
P16220Cyclic AMP-responsive element-binding protein 1CREB1
P15509Granulocyte-macrophage colony-stimulating factorCSF2RA
P17538Chymotrypsinogen BCTRB1
P07858Cathepsin BCTSB
P10145Interleukin-8CXCL8
Q16850Lanosterol 14-alpha demethylaseCYP51A1
Q9UBM77-Dehydrocholesterol reductaseDHCR7
P27487Dipeptidyl peptidase IVDPP4
P21728Dopamine D1 receptorDRD1
Q9NRD8Dual oxidase 2DUOX2
Q6UWV6Intestinal alkaline sphingomyelinaseENPP7
Q99814Endothelial PAS domain-containing protein 1EPAS1
P03372Estrogen receptorESR1
Q92731Estrogen receptor betaESR2
P00742Coagulation factor XaF10
P00734ThrombinF2
P08709Coagulation factor VIIF7
P48023Tumor necrosis factor ligand superfamily member 6FASLG
P49327Fatty acid synthaseFASN
P05230Fibroblast growth factor 1FGF1
P09038Heparin-binding growth factor 2FGF2
P01100Proto-oncogene c-FosFOS
P14867Gamma-aminobutyric acid receptor subunit alpha-1GABRA1
P47869Gamma-aminobutyric-acid receptor alpha-2 subunitGABRA2
P34903Gamma-aminobutyric-acid receptor alpha-3 subunitGABRA3
P31644Gamma-aminobutyric-acid receptor alpha-5 subunitGABRA5
P17677NeuromodulinGAP43
Q8TDU6G-protein coupled bile acid receptor 1GPBAR1
P42262Glutamate receptor 2GRIA2
P49841Glycogen synthase kinase-3 betaGSK3B
Q9UII4Probable E3 ubiquitin-protein ligase HERC5HERC5
P09601Heme oxygenase 1HMOX1
P01112GTPase HRasHRAS
P28845Corticosteroid 11-beta-dehydrogenase isozyme 1HSD11B1
P80365Corticosteroid 11-beta-dehydrogenase isozyme 2HSD11B2
P08238Heat shock protein HSP 90HSP90AB1
P282235-Hydroxytryptamine 2A receptorHTR2A
P460985-Hydroxytryptamine receptor 3AHTR3A
P05362Intercellular adhesion molecule 1ICAM1
P01857Ig gamma-1 chain C regionIGHG1
P01584Interleukin-1 betaIL1B
P60568Interleukin-2IL2
P05231Interleukin-6IL6
O15357Phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase 2INPPL1
P05412Transcription factor AP-1JUN
Q12809Potassium voltage-gated channel subfamily H member 2KCNH2
Q12791Calcium-activated potassium channel subunit alpha 1KCNMA1
O75164Lysine-specific demethylase 4AKDM4A
P35968Vascular endothelial growth factor receptor 2KDR
Q99732Lipopolysaccharide-induced tumor necrosis factor-alpha factorLITAF
P09960Leukotriene A-4 hydrolaseLTA4H
P21397Amine oxidase [flavin-containing] AMAOA
P27338Amine oxidase [flavin-containing] BMAOB
P11137Microtubule-associated protein 2MAP2
Q16539Mitogen-activated protein kinase 14MAPK14
P45983Mitogen-activated protein kinase 8MAPK8
Q13387C-Jun-amino-terminal kinase-interacting protein 2MAPK8IP2
Q07820Induced myeloid leukemia cell differentiation protein Mcl-1MCL1
P14174L-Dopachrome tautomeraseMIF
P03956Interstitial collagenaseMMP1
P09238Stromelysin-2MMP10
P0825372 kDa type IV collagenaseMMP2
P08254Stromelysin-1MMP3
P14780Matrix metalloproteinase-9MMP9
P42345Serine/threonine-protein kinase mTORMTOR
P14598Neutrophil cytosol factor 1NCF1
Q15788Nuclear receptor coactivator 1NCOA1
Q15596Nuclear receptor coactivator 2NCOA2
Q9GZQ4Neuromedin-U receptor 2NMUR2
P35228Nitric oxide synthase, inducibleNOS2
P29474Nitric oxide synthase, endothelialNOS3
P15559NAD(P)H dehydrogenase [quinone] 1NQO1
P04150Glucocorticoid receptorNR3C1
P08235Mineralocorticoid receptorNR3C2
P01111GTPase NRasNRAS
P78380Oxidized low-density lipoprotein receptor 1OLR1
P35372Mu-type opioid receptorOPRM1
P07237Protein disulfide-isomeraseP4HB
Q14432CGMP-inhibited 3′,5′-cyclic phosphodiesterase APDE3A
P16284Platelet endothelial cell adhesion moleculePECAM1
P06401Progesterone receptorPGR
P42336Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoformPIK3CA
P48736Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit, gamma isoformPIK3CG
P11309Proto-oncogene serine/threonine-protein kinase Pim-1PIM1
P61925cAMP-dependent protein kinase inhibitor alphaPKIA
P00749Urokinase-type plasminogen activatorPLAU
P191741-Phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1PLCG1
P09884DNA polymerase alpha catalytic subunitPOLA1
P06746DNA polymerase betaPOLB
P54098DNA polymerase catalytic subunitPOLG
P27169Serum paraoxonase/arylesterase 1PON1
Q03181Peroxisome proliferator activated receptor deltaPPARD
P37231Peroxisome proliferator activated receptor gammaPPARG
P17612mRNA of PKA catalytic subunit C-alphaPRKACA
P17252Protein kinase C alpha typePRKCA
P05129Protein kinase C gamma typePRKCG
P07477Trypsin-1PRSS1
P43115Prostaglandin E2 receptor EP3 subtypePTGER3
O14684Prostaglandin E synthasePTGES
P23219Prostaglandin G/H synthase 1PTGS1
P35354Prostaglandin G/H synthase 2PTGS2
P18031Protein-tyrosine phosphatase 1BPTPN1
P17706T-cell protein-tyrosine phosphatasePTPN2
P29350Hematopoietic cell protein-tyrosine phosphatasePTPN6
P11217Glycogen phosphorylase, muscle formPYGM
Q04206Transcription factor p65RELA
P19793Retinoic acid receptor RXR-alphaRXRA
Q14524Sodium channel protein type 5 subunit alphaSCN5A
P16581E-selectinSELE
Q9HAS3Solute carrier family 28 member 3SLC28A3
O43826Glucose-6-phosphate translocaseSLC37A4
P13866Sodium/glucose cotransporter 1SLC5A1
P31639Sodium/glucose cotransporter 2SLC5A2
Q9NY91Low affinity sodium-glucose cotransporterSLC5A4
P23975Sodium-dependent noradrenaline transporterSLC6A2
Q01959Sodium-dependent dopamine transporterSLC6A3
P31645Sodium-dependent serotonin transporterSLC6A4
Q9Y6L6Solute carrier organic anion transporter family member 1B1SLCO1B1
P40763Signal transducer and activator of transcription 3STAT3
P59538Taste receptor type 2 member 31TAS2R31
P01137Transforming growth factor beta-1TGFB1
P01375Tumor necrosis factorTNF
P11388DNA topoisomerase II alphaTOP2A
P04637Cellular tumor antigen p53TP53
P17752Tryptophan 5-hydroxylase 1TPH1
P14679TyrosinaseTYR
P176435,6-dihydroxyindole-2-carboxylic acid oxidaseTYRP1
P15692Vascular endothelial growth factor AVEGFA
P47989Xanthine dehydrogenase/oxidaseXDH