Tongxinluo Regulates Expression of Tight Junction Proteins and Alleviates Endothelial Cell Monolayer Hyperpermeability via ERK-1/2 Signaling Pathway in Oxidized Low-Density Lipoprotein-Induced Human Umbilical Vein Endothelial Cells

Figure 1

TXL decreased ox-LDL-induced hyperpermeability in HUVECs. HUVECs were treated with ox-LDL (120 μg/mL) for 24 h prior to treatment with TXL (200 μg/mL) for 4 h. At different time points, the endothelial permeability was determined by the transwell assay. Quantitative analysis was performed by measuring FD40 fluorescence intensity relative to the control. The data were obtained from three independent experiments. Each bar represents the mean (±SD) of three independent experiments. , versus control, , and versus ox-LDL group.