Tongxinluo Regulates Expression of Tight Junction Proteins and Alleviates Endothelial Cell Monolayer Hyperpermeability via ERK-1/2 Signaling Pathway in Oxidized Low-Density Lipoprotein-Induced Human Umbilical Vein Endothelial Cells

<div>TXL restored ZO-1, occludin, and claudin1 expression in ox-LDL-treated HUVECs. HUVECs were treated with ox-LDL (120 <i>μ</i>g/mL) for 24 h, prior to treatment with TXL (200 <i>μ</i>g/mL) for another 4 h, with or without incubation with PD98059 (20 <i>μ</i>M) for 0.5 h. Immunofluorescent staining detection of ZO-1 (a), occludin (b), and claudin1 (c) expression.</div>

Evidence-Based Complementary and Alternative Medicine

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Figure 4: Tongxinluo Regulates Expression of Tight Junction Proteins and Alleviates Endothelial Cell Monolayer Hyperpermeability via ERK-1/2 Signaling Pathway in Oxidized Low-Density Lipoprotein-Induced Human Umbilical Vein Endothelial Cells 

Figure 4 | Tongxinluo Regulates Expression of Tight Junction Proteins and Alleviates Endothelial Cell Monolayer Hyperpermeability via ERK-1/2 Signaling Pathway in Oxidized Low-Density Lipoprotein-Induced Human Umbilical Vein Endothelial Cells 