Table of Contents Author Guidelines Submit a Manuscript
Evidence-Based Complementary and Alternative Medicine
Volume 2017 (2017), Article ID 4295680, 8 pages
https://doi.org/10.1155/2017/4295680
Research Article

Solanum paranense Extracts and Solanine Present Anti-Inflammatory Activity in an Acute Skin Inflammation Model in Mice

1Laboratório de Análises Fitoquímicas, Programa de Pós-Graduação em Ciências Farmacêuticas, Universidade Federal de Santa Maria, 97.105-900 Santa Maria, RS, Brazil
2Laboratório de Neurotoxicidade e Psicofarmacologia, Programa de Pós-Graduação em Ciências Biológicas: Bioquímica Toxicológica, Universidade Federal de Santa Maria, 97.105-900 Santa Maria, RS, Brazil

Correspondence should be addressed to Sara Marchesan Oliveira; moc.liamtoh@nasehcramaras

Received 17 January 2017; Revised 3 April 2017; Accepted 20 April 2017; Published 24 May 2017

Academic Editor: Jairo Kennup Bastos

Copyright © 2017 Mariana Piana et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

The aim of the study was to evaluate the anti-inflammatory activity of the S. paranense crude extract, S. paranense alkaloid fraction, and solanine alkaloid. These samples reduce the croton oil-induced ear edema in a dose-dependent manner and a maximum inhibition of 81%, 98%, and 80% in the doses of 1.0, 0.73, and 0.37 mg/ear, respectively. Moreover, the samples inhibit the MPO activity with an inhibition maximum of 51%, 40%, and 46% in the doses of 1.0, 0.73, and 0.37 mg/ear, respectively. Similar results were found for dexamethasone 0.10 mg/ear (positive control), which showed inhibitions of ear edema and MPO activity of 100% and 65%, respectively. These results found probably are related to the presence of solanine which is present in significant quantity in the alkaloid fraction and others as rutin and rosmarinic, chlorogenic, and gallic acids. These results support the use of S. paranense for the treatment of inflammatory skin disorders.