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Evidence-Based Complementary and Alternative Medicine
Volume 2017, Article ID 4537974, 13 pages
https://doi.org/10.1155/2017/4537974
Research Article

Sodium Tanshinone IIA Sulfonate Prevents Radiation-Induced Toxicity in H9c2 Cardiomyocytes

1School of Clinical Medicine, Gansu University of Traditional Chinese Medicine, Lanzhou, Gansu 730000, China
2The Institute of Medical Genetics, School of Basic Medical Sciences, Lanzhou University, Lanzhou 730000, China
3Gansu Cardiovascular Institute, Lanzhou 730050, China
4School of Stomatology, Lanzhou University, Lanzhou, Gansu 730000, China
5School of Clinical Medicine, Ningxia Medical University, Yinchuan, Ningxia Hui Autonomous Region 750000, China
6Department of Cardiology, Gansu Provincial Hospital, Lanzhou, Gansu 730000, China
7Radiology Department, Gansu Provincial Hospital, Lanzhou, Gansu 730000, China

Correspondence should be addressed to Ping Xie; moc.361@66eixgnip and Bin Liu; nc.ude.uzl@qkbuil

Received 10 August 2016; Revised 11 January 2017; Accepted 19 January 2017; Published 12 March 2017

Academic Editor: Raffaele Capasso

Copyright © 2017 Wenjing Zhang et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. K. C. Oeffinger, P. C. Nathan, and L. C. M. Kremer, “Challenges after curative treatment for childhood cancer and long-term follow up of survivors,” Hematology/Oncology Clinics of North America, vol. 24, no. 1, pp. 129–149, 2010. View at Publisher · View at Google Scholar · View at Scopus
  2. K. C. Oeffinger, A. C. Mertens, C. A. Sklar et al., “Chronic health conditions in adult survivors of childhood cancer,” New England Journal of Medicine, vol. 355, no. 15, pp. 1572–1582, 2006. View at Publisher · View at Google Scholar · View at Scopus
  3. G. T. Armstrong, T. Kawashima, W. Leisenring et al., “Aging and risk of severe, disabling, life-threatening, and fatal events in the childhood cancer survivor study,” Journal of Clinical Oncology, vol. 32, no. 12, pp. 1218–1227, 2014. View at Publisher · View at Google Scholar · View at Scopus
  4. M. M. Hudson, K. K. Ness, J. G. Gurney et al., “Clinical ascertainment of health outcomes among adults treated for childhood cancer,” JAMA, vol. 309, no. 22, pp. 2371–2381, 2013. View at Publisher · View at Google Scholar · View at Scopus
  5. S. L. Galper, J. B. Yu, P. M. Mauch et al., “Clinically significant cardiac disease in patients with Hodgkin lymphoma treated with mediastinal irradiation,” Blood, vol. 117, no. 2, pp. 412–418, 2011. View at Publisher · View at Google Scholar · View at Scopus
  6. H. J. H. van der Pal, E. C. van Dalen, L. C. M. Kremer, P. J. M. Bakker, and F. E. van Leeuwen, “Risk of morbidity and mortality from cardiovascular disease following radiotherapy for childhood cancer: a systematic review,” Cancer Treatment Reviews, vol. 31, no. 3, pp. 173–185, 2005. View at Publisher · View at Google Scholar · View at Scopus
  7. H. J. Van Der Pal, E. C. Van Dalen, E. Van Delden et al., “High risk of symptomatic cardiac events in childhood cancer survivors,” Journal of Clinical Oncology, vol. 30, no. 13, pp. 1429–1437, 2012. View at Publisher · View at Google Scholar · View at Scopus
  8. K. Bacher, E. Bogaert, R. Lapere, D. De Wolf, and H. Thierens, “Patient-specific dose and radiation risk estimation in pediatric cardiac catheterization,” Circulation, vol. 111, no. 1, pp. 83–89, 2005. View at Publisher · View at Google Scholar · View at Scopus
  9. E. C. Martin, A. P. Olson, C. N. Steeg, and W. J. Casarella, “Radiation exposure to the pediatric patient during cardiac catheterization and angiocardiography. Emphasis on the thyroid gland,” Circulation, vol. 64, no. 1, pp. 153–158, 1981. View at Publisher · View at Google Scholar · View at Scopus
  10. A. Hoffmann, P. Engelfriet, and B. Mulder, “Radiation exposure during follow-up of adults with congenital heart disease,” International Journal of Cardiology, vol. 118, no. 2, pp. 151–153, 2007. View at Publisher · View at Google Scholar · View at Scopus
  11. E. Picano, E. Vañó, M. M. Rehani et al., “The appropriate and justified use of medical radiation in cardiovascular imaging: a position document of the ESC Associations of Cardiovascular Imaging, Percutaneous Cardiovascular Interventions and Electrophysiology,” European Heart Journal, vol. 35, no. 10, pp. 665–672, 2014. View at Publisher · View at Google Scholar · View at Scopus
  12. D. Harake, V. I. Franco, J. M. Henkel, T. L. Miller, and S. E. Lipshultz, “Cardiotoxicity in childhood cancer survivors: strategies for prevention and management,” Future Cardiology, vol. 8, no. 4, pp. 647–670, 2012. View at Publisher · View at Google Scholar · View at Scopus
  13. G. D. Cilliers, I. S. Harper, and A. Lochner, “Radiation-induced changes in the ultrastructure and mechanical function of the rat heart,” Radiotherapy and Oncology, vol. 16, no. 4, pp. 311–326, 1989. View at Publisher · View at Google Scholar · View at Scopus
  14. Z. Chen, Z. Hu, Z. Lu et al., “Differential MicroRNA profiling in a cellular hypoxia reoxygenation model upon posthypoxic propofol treatment reveals alterations in autophagy signaling network,” Oxidative Medicine and Cellular Longevity, vol. 2013, Article ID 378484, 11 pages, 2013. View at Publisher · View at Google Scholar · View at Scopus
  15. E. Mezzaroma, X. Di, P. Graves et al., “A mouse model of radiation-induced cardiomyopathy,” International Journal of Cardiology, vol. 156, no. 2, pp. 231–233, 2012. View at Publisher · View at Google Scholar · View at Scopus
  16. R. F. Dillenburg, P. Nathan, and L. Mertens, “Educational paper: Decreasing the burden of cardiovascular disease in childhood cancer survivors: An update for the pediatrician,” European Journal of Pediatrics, vol. 172, no. 9, pp. 1149–1160, 2013. View at Publisher · View at Google Scholar · View at Scopus
  17. T. E. Sharp and J. C. George, “Stem cell therapy and breast cancer treatment: review of stem cell research and potential therapeutic impact against cardiotoxicities due to breast cancer treatment,” Frontiers in Oncology, vol. 4, article 299, 2014. View at Publisher · View at Google Scholar · View at Scopus
  18. I. Gürses, M. Özeren, M. Serin, N. Yücel, and H. Ş. Erkal, “Histopathological evaluation of melatonin as a protective agent in heart injury induced by radiation in a rat model,” Pathology, Research and Practice, vol. 210, no. 12, pp. 863–871, 2014. View at Publisher · View at Google Scholar · View at Scopus
  19. B. Jiang, L. Zhang, Y. Wang et al., “Tanshinone IIA sodium sulfonate protects against cardiotoxicity induced by doxorubicin in vitro and in vivo,” Food and Chemical Toxicology, vol. 47, no. 7, pp. 1538–1544, 2009. View at Publisher · View at Google Scholar · View at Scopus
  20. R. Yang, A. Liu, X. Ma, L. Li, D. Su, and J. Liu, “Sodium tanshinone IIA sulfonate protects cardiomyocytes against oxidative stress-mediated apoptosis through inhibiting JNK activation,” Journal of Cardiovascular Pharmacology, vol. 51, no. 4, pp. 396–401, 2008. View at Publisher · View at Google Scholar · View at Scopus
  21. F. Maione, V. De Feo, E. Caiazzo, L. De Martino, C. Cicala, and N. Mascolo, “Tanshinone IIA, a major component of Salvia milthorriza Bunge, inhibits platelet activation via Erk-2 signaling pathway,” Journal of Ethnopharmacology, vol. 155, no. 2, pp. 1236–1242, 2014. View at Publisher · View at Google Scholar
  22. X. Su, Z. Yao, S. Li, and H. Sun, “Synergism of Chinese herbal medicine: illustrated by danshen compound,” Evidence-based Complementary and Alternative Medicine, vol. 2016, Article ID 7279361, 10 pages, 2016. View at Publisher · View at Google Scholar · View at Scopus
  23. H. Xu and K.-J. Chen, “Integrating traditional medicine with biomedicine towards a patient-centered healthcare system,” Chinese Journal of Integrative Medicine, vol. 17, no. 2, pp. 83–84, 2011. View at Publisher · View at Google Scholar · View at Scopus
  24. Q. Shang, H. Xu, and L. Huang, “Tanshinone IIA: a promising natural cardioprotective agent,” Evidence-Based Complementary and Alternative Medicine, vol. 2012, Article ID 716459, 7 pages, 2012. View at Publisher · View at Google Scholar · View at Scopus
  25. J. Fu, H. Huang, J. Liu, R. Pi, J. Chen, and P. Liu, “Tanshinone IIA protects cardiac myocytes against oxidative stress-triggered damage and apoptosis,” European Journal of Pharmacology, vol. 568, no. 1-3, pp. 213–221, 2007. View at Publisher · View at Google Scholar · View at Scopus
  26. J. Tang, C. Zhan, and J. Zhou, “Effects of tanshinone IIA on transforming growth factor β1-Smads signal pathway in renal interstitial fibroblasts of rats,” Journal of Huazhong University of Science and Technology—Medical Science, vol. 28, no. 5, pp. 539–542, 2008. View at Publisher · View at Google Scholar · View at Scopus
  27. L.-N. Liu, L. Shi, S.-C. Li, W.-J. Zhang, Y. Zhang, and Z.-P. Zhang, “Protective role of Rheum tanguticum polysaccharide 1 in radiation-induced intestinal mucosal injury,” Iranian Journal of Pharmaceutical Research, vol. 14, no. 3, pp. 833–841, 2015. View at Google Scholar · View at Scopus
  28. N. L. Weintraub, W. K. Jones, and D. Manka, “Understanding radiation-induced vascular disease,” Journal of the American College of Cardiology, vol. 55, no. 12, pp. 1237–1239, 2010. View at Publisher · View at Google Scholar · View at Scopus
  29. L. Ait-Ali, M. G. Andreassi, I. Foffa, I. Spadoni, E. Vano, and E. Picano, “Cumulative patient effective dose and acute radiation-induced chromosomal DNA damage in children with congenital heart disease,” Heart, vol. 96, no. 4, pp. 269–274, 2010. View at Publisher · View at Google Scholar · View at Scopus
  30. N. Magné, C. Chargari, D. MacDermed et al., “Tomorrow's targeted therapies in breast cancer patients: what is the risk for increased radiation-induced cardiac toxicity?” Critical Reviews in Oncology/Hematology, vol. 76, no. 3, pp. 186–195, 2010. View at Publisher · View at Google Scholar · View at Scopus
  31. S. E. Lipshultz, S. R. Lipsitz, S. E. Sallan et al., “Long-term enalapril therapy for left ventricular dysfunction in doxorubicin-treated survivors of childhood cancer,” Journal of Clinical Oncology, vol. 20, no. 23, pp. 4517–4522, 2002. View at Publisher · View at Google Scholar · View at Scopus
  32. B.-L. Zhao, W. Jiang, Y. Zhao, J.-W. Hou, and W.-J. Xin, “Scavenging effects of Salvia miltiorrhiza on free radicals and its protection for myocardial mitochondrial membranes from ischemia-reperfusion injury,” Biochemistry and Molecular Biology International, vol. 38, no. 6, pp. 1171–1182, 1996. View at Google Scholar · View at Scopus
  33. S. Ilavenil, D. H. Kim, Y.-I. Jeong et al., “Trigonelline protects the cardiocyte from hydrogen peroxide induced apoptosis in H9c2 cells,” Asian Pacific Journal of Tropical Medicine, vol. 8, no. 4, pp. 263–268, 2015. View at Publisher · View at Google Scholar · View at Scopus
  34. T. T. Renault, O. Teijido, B. Antonsson, L. M. Dejean, and S. Manon, “Regulation of Bax mitochondrial localization by Bcl-2 and Bcl-xL: keep your friends close but your enemies closer,” International Journal of Biochemistry and Cell Biology, vol. 45, no. 1, pp. 64–67, 2013. View at Publisher · View at Google Scholar · View at Scopus
  35. J. C. Gómez-Fernández, “Functions of the C-terminal domains of apoptosis-related proteins of the Bcl-2 family,” Chemistry and Physics of Lipids, vol. 183, pp. 77–90, 2014. View at Publisher · View at Google Scholar · View at Scopus
  36. S. Snigdha, E. D. Smith, G. A. Prieto, and C. W. Cotman, “Caspase-3 activation as a bifurcation point between plasticity and cell death,” Neuroscience Bulletin, vol. 28, no. 1, pp. 14–24, 2012. View at Publisher · View at Google Scholar · View at Scopus
  37. Y. Wang, S. Huang, V. P. Sah et al., “Cardiac muscle cell hypertrophy and apoptosis induced by distinct members of the p38 mitogen-activated protein kinase family,” Journal of Biological Chemistry, vol. 273, no. 4, pp. 2161–2168, 1998. View at Publisher · View at Google Scholar · View at Scopus
  38. M. S. Marber, B. Rose, and Y. Wang, “The p38 mitogen-activated protein kinase pathway—a potential target for intervention in infarction, hypertrophy, and heart failure,” Journal of Molecular and Cellular Cardiology, vol. 51, no. 4, pp. 485–490, 2011. View at Publisher · View at Google Scholar · View at Scopus
  39. R. Aikawa, I. Komuro, T. Yamazaki et al., “Oxidative stress activates extracellular signal-regulated kinases through Src and Ras in cultured cardiac myocytes of neonatal rats,” Journal of Clinical Investigation, vol. 100, no. 7, pp. 1813–1821, 1997. View at Publisher · View at Google Scholar · View at Scopus