The Effect of Chunghyul-Dan on Hyperventilation-Induced Carbon Dioxide Reactivity of the Middle Cerebral Artery in Normal Subjects: A Dose-Dependent Study

Table 2

Changes in hyperventilation-induced CO₂ reactivity (%/min) before and after CHD administration.

()		(T0) Before administration	After administration
			T1 (1 hr)	T2 (2 hr)	T3 (3 hr)
Control						<0.001	—	0.090
CHD	300 mg						1.000	0.501
CHD	600 mg						0.024	<0.001
CHD	1200 mg						0.034	<0.001

All data are means ± SD. CHD, chunghyul-dan; hr, hour.
: time × treatment interaction effect by two-way repeated measures analysis of variation (RM ANOVA).
: post hoc test by Bonferroni multiple comparisons versus control after two-way RM ANOVA.
: within-measure (time) effect by one-way RM ANOVA.
< 0.05 versus before administration (baseline) by Bonferroni multiple comparisons after one-way RM ANOVA.