Cyclocarya paliurus (Batal.) Ijinskaja Aqueous Extract (CPAE) Ameliorates Obesity by Improving Insulin Signaling in the Hypothalamus of a Metabolic Syndrome Rat Model

Figure 5

CPAE activates the insulin-signaling pathway in the hypothalamus of SHR/cp rats. (a) The phosphorylation level of InsR, (b) the phosphorylation level of IRS1tyr989, (c) the level of m-PI3Kp85, (d) the phosphorylation level of Akt, (e) the phosphorylation level of FoXO1, (f) the protein expression level of POMC, and (g) NPY of SHR/cp rats treated with 0.5 g/kg CPAE or untreated controls. All of the results were determined by Western blot analysis as described in Materials and Methods. Values are expressed as the mean ± SD. and versus control group. per group.

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