Antiaging and Anxiolytic Effects of Combinatory Formulas Based on Four Medicinal Herbs

Figure 8

Anxiolytic effects of single herbs blocked by the receptor BZ-site antagonist flumazenil. Mice were treated with saline vehicle (Veh), single-herb extract (120 mg/kg of oral B, Y, P, or A) with or without flumazenil (namely F, 1.25 mg/kg i.p). Anxiolytic effect was evaluated based on time spent in open arms. Data represent mean ± SD. ^###() indicates significant difference between test group receiving single herb without flumazenil and Veh group, whereas () indicates significant difference between test group receiving single herb with flumazenil and test group receiving single herb without flumazenil, based on one-way ANOVA test followed by Newman-Keuls test.

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