Table of Contents Author Guidelines Submit a Manuscript
Evidence-Based Complementary and Alternative Medicine
Volume 2017 (2017), Article ID 4837839, 9 pages
https://doi.org/10.1155/2017/4837839
Research Article

Acute and Subacute Oral Toxicity Evaluation of Eriobotrya japonica Leaf Triterpene Acids in ICR Mice

1College of Chemistry, Fuzhou University, Fuzhou 350116, China
2Institute of Pharmaceutical Biotechnology and Engineering, Fuzhou University, Fuzhou 350116, China

Correspondence should be addressed to Feng Li; moc.nuyila@6769gnefil and Yanghao Guo; moc.nuyila@ougoahgnay

Received 20 December 2016; Accepted 13 February 2017; Published 16 March 2017

Academic Editor: Ken Yasukawa

Copyright © 2017 Feng Li et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. Chinese Pharmacopoeia Committee, Chinese Pharmacopoeia, vol. 1, Chinese Medical Science and Technology Press, Beijing, China, 2010.
  2. T. Uto, A. Sakamoto, N. H. Tung et al., “Anti-proliferative activities and apoptosis induction by triterpenes derived from Eriobotrya japonica in human leukemia cell lines,” International Journal of Molecular Sciences, vol. 14, no. 2, pp. 4106–4120, 2013. View at Publisher · View at Google Scholar · View at Scopus
  3. W. L. Li, “Progress in studies on phytochemistry and biological activity of Folium Eriobotryae,” Medicinal and Aromatic Plant Science and Biotechnology, vol. 2, no. 2, pp. 18–23, 2008. View at Google Scholar
  4. H.-Y. Ho, W.-C. Lin, S. Kitanaka, C.-T. Chang, and J.-B. Wu, “Analysis of bioactive triterpenes in Eriobotrya japonica Lindl. by high-performance liquid chromatography,” Journal of Food and Drug Analysis, vol. 16, no. 6, pp. 41–45, 2008. View at Google Scholar · View at Scopus
  5. S. Taniguchi, Y. Imayoshi, E. Kobayashi et al., “Production of bioactive triterpenes by Eriobotrya japonica calli,” Phytochemistry, vol. 59, no. 3, pp. 315–323, 2002. View at Publisher · View at Google Scholar · View at Scopus
  6. H. Ito, E. Kobayashi, S.-H. Li et al., “Antitumor activity of compounds isolated from leaves of Eriobotrya japonica,” Journal of Agricultural and Food Chemistry, vol. 50, no. 8, pp. 2400–2403, 2002. View at Publisher · View at Google Scholar · View at Scopus
  7. Y. Huang, J. Li, Q. Cao et al., “Anti-oxidative effect of triterpene acids of Eriobotrya japonica (Thunb.) Lindl. leaf in chronic bronchitis rats,” Life Sciences, vol. 78, no. 23, pp. 2749–2757, 2006. View at Publisher · View at Google Scholar · View at Scopus
  8. H. Lü, J. Chen, W. L. Li et al., “Hypoglycemic and hypolipidemic effects of the total triterpene acid fraction from Folium Eriobotryae,” Journal of Ethnopharmacology, vol. 122, no. 3, pp. 486–491, 2009. View at Publisher · View at Google Scholar · View at Scopus
  9. M. Sánchez-González, G. Lozano-Mena, M. E. Juan, A. García-Granados, and J. M. Planas, “Assessment of the safety of maslinic acid, a bioactive compound from Olea europaea L.,” Molecular Nutrition & Food Research, vol. 57, no. 2, pp. 339–346, 2013. View at Publisher · View at Google Scholar · View at Scopus
  10. Y. Fujiwara, K. Takaishi, J. Nakao et al., “Corosolic acid enhances the antitumor effects of chemotherapy on epithelial ovarian cancer by inhibiting signal transducer and activator of transcription 3 signaling,” Oncology Letters, vol. 6, no. 6, pp. 1619–1623, 2013. View at Publisher · View at Google Scholar · View at Scopus
  11. S. Zhang, D. Ding, X. Zhang, L. Shan, and Z. Liu, “Maslinic acid induced apoptosis in bladder cancer cells through activating p38 MAPK signaling pathway,” Molecular and Cellular Biochemistry, vol. 392, no. 1-2, pp. 281–287, 2014. View at Publisher · View at Google Scholar · View at Scopus
  12. Z. Tian, G. Lin, R.-X. Zheng, F. Huang, M.-S. Yang, and P.-G. Xiao, “Anti-hepatoma activity and mechanism of ursolic acid and its derivatives isolates from Aralia decaisneana,” World Journal of Gastroenterology, vol. 12, no. 6, pp. 874–879, 2006. View at Publisher · View at Google Scholar · View at Scopus
  13. S.-L. Yan, C.-Y. Huang, S.-T. Wu, and M.-C. Yin, “Oleanolic acid and ursolic acid induce apoptosis in four human liver cancer cell lines,” Toxicology in Vitro, vol. 24, no. 3, pp. 842–848, 2010. View at Publisher · View at Google Scholar · View at Scopus
  14. A. A. Ramos, C. Pereira-Wilson, and A. R. Collins, “Protective effects of Ursolic acid and Luteolin against oxidative DNA damage include enhancement of DNA repair in Caco-2 cells,” Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis, vol. 692, no. 1-2, pp. 6–11, 2010. View at Publisher · View at Google Scholar · View at Scopus
  15. H.-X. Chen, P. He, Z.-J. Xu, G.-Y. You, W.-L. Liu, and Y.-Y. Xiao, “Preparation of oleanolic acid intravenous emulsions and its pharmacokinetics in rats,” Chinese Pharmaceutical Journal, vol. 46, no. 13, pp. 1023–1026, 2011. View at Google Scholar · View at Scopus
  16. P.-P. Wu, K. Zhang, Y.-J. Lu, P. He, and S.-Q. Zhao, “In vitro and in vivo evaluation of the antidiabetic activity of ursolic acid derivatives,” European Journal of Medicinal Chemistry, vol. 80, pp. 502–508, 2014. View at Publisher · View at Google Scholar · View at Scopus
  17. T. Miura, N. Ueda, K. Yamada et al., “Antidiabetic effects of corosolic acid in KK-Ay diabetic mice,” Biological and Pharmaceutical Bulletin, vol. 29, no. 3, pp. 585–587, 2006. View at Publisher · View at Google Scholar · View at Scopus
  18. X. Wang, Y.-L. Li, H. Wu et al., “Antidiabetic effect of oleanolic acid: a promising use of a traditional pharmacological agent,” Phytotherapy Research, vol. 25, no. 7, pp. 1031–1040, 2011. View at Publisher · View at Google Scholar · View at Scopus
  19. J. Lu, D.-M. Wu, Y.-L. Zheng et al., “Ursolic acid attenuates D-galactose-induced inflammatory response in mouse prefrontal cortex through inhibiting AGEs/RAGE/NF-κB pathway activation,” Cerebral Cortex, vol. 20, no. 11, pp. 2540–2548, 2010. View at Publisher · View at Google Scholar · View at Scopus
  20. W. Lee, E.-J. Yang, S.-K. Ku, K.-S. Song, and J.-S. Bae, “Anti-inflammatory effects of oleanolic acid on LPS-induced inflammation in vitro and in vivo,” Inflammation, vol. 36, no. 1, pp. 94–102, 2013. View at Publisher · View at Google Scholar · View at Scopus
  21. M. C. Aguirre, C. Delporte, N. Backhouse et al., “Topical anti-inflammatory activity of 2α-hydroxy pentacyclic triterpene acids from the leaves of Ugni molinae,” Bioorganic & Medicinal Chemistry, vol. 14, no. 16, pp. 5673–5677, 2006. View at Publisher · View at Google Scholar · View at Scopus
  22. Y. Yamaguchi, K. Yamada, N. Yoshikawa, K. Nakamura, J. Haginaka, and M. Kunitomo, “Corosolic acid prevents oxidative stress, inflammation and hypertension in SHR/NDmcr-cp rats, a model of metabolic syndrome,” Life Sciences, vol. 79, no. 26, pp. 2474–2479, 2006. View at Publisher · View at Google Scholar · View at Scopus
  23. European Parliament and the Council of the European Union, “Regulation (EC) No. 1272/2008 of the European parliament and of the council of 16 December 2008 on classification, labelling and packaging of substances and mixtures, amending and repealing Directives 67/548/EEC and 1999/45/EC, and amending Regulation (EC) No. 1907/2006,” Official Journal of the European Union, vol. 353, 2008. View at Google Scholar
  24. C. L. de Melo, M. G. R. Queiroz, S. G. C. Fonseca et al., “Oleanolic acid, a natural triterpenoid improves blood glucose tolerance in normal mice and ameliorates visceral obesity in mice fed a high-fat diet,” Chemico-Biological Interactions, vol. 185, no. 1, pp. 59–65, 2010. View at Publisher · View at Google Scholar · View at Scopus
  25. C.-C. Shih, C.-H. Lin, and J.-B. Wu, “Eriobotrya japonica improves hyperlipidemia and reverses insulin resistance in high-fat-fed mice,” Phytotherapy Research, vol. 24, no. 12, pp. 1769–1780, 2010. View at Publisher · View at Google Scholar · View at Scopus
  26. Rosidah, M. F. Yam, A. Sadikun, M. Ahmad, G. A. Akowuah, and M. Z. Asmawi, “Toxicology evaluation of standardized methanol extract of Gynura procumbens,” Journal of Ethnopharmacology, vol. 123, no. 2, pp. 244–249, 2009. View at Publisher · View at Google Scholar · View at Scopus
  27. H. G. Jeong, “Inhibition of cytochrome P450 2E1 expression by oleanolic acid: hepatoprotective effects against carbon tetrachloride-induced hepatic injury,” Toxicology Letters, vol. 105, no. 3, pp. 215–222, 1999. View at Publisher · View at Google Scholar · View at Scopus
  28. B. Shukla, P. K. S. Visen, G. K. Patnaik et al., “Hepatoprotective activity in the rat of ursolic acid isolated from Eucalyptus hybrid,” Phytotherapy Research, vol. 6, no. 2, pp. 74–79, 1992. View at Publisher · View at Google Scholar · View at Scopus
  29. K. Yamada, M. Hosokawa, C. Yamada et al., “Dietary corosolic acid ameliorates obesity and hepatic steatosis in KK-Ay mice,” Biological and Pharmaceutical Bulletin, vol. 31, no. 4, pp. 651–655, 2008. View at Publisher · View at Google Scholar · View at Scopus
  30. J. Liu, H. Sun, X. Wang, D. Mu, H. Liao, and L. Zhang, “Effects of oleanolic acid and maslinic acid on hyperlipidemia,” Drug Development Research, vol. 68, no. 5, pp. 261–266, 2007. View at Publisher · View at Google Scholar · View at Scopus
  31. H. Olson, G. Betton, D. Robinson et al., “Concordance of the toxicity of pharmaceuticals in humans and in animals,” Regulatory Toxicology and Pharmacology, vol. 32, no. 1, pp. 56–67, 2000. View at Publisher · View at Google Scholar · View at Scopus
  32. C.-G. Son, S.-H. Han, J.-H. Cho et al., “Induction of hemopoiesis by saenghyuldan, a mixture of ginseng radix, paeoniae radix alba,and hominis placenta extracts,” Acta Pharmacologica Sinica, vol. 24, no. 2, pp. 120–126, 2003. View at Google Scholar · View at Scopus
  33. A. D. Kandhare, S. L. Bodhankar, V. Mohan, and P. A. Thakurdesai, “Acute and repeated doses (28 days) oral toxicity study of glycosides based standardized fenugreek seed extract in laboratory mice,” Regulatory Toxicology and Pharmacology, vol. 72, no. 2, pp. 323–334, 2015. View at Publisher · View at Google Scholar · View at Scopus