Amelioration of Scopolamine-Induced Learning and Memory Impairment by α-Pinene in C57BL/6 Mice

Figure 3

Protective effect of APN on the learning and memory deficit induced by SCO in passive avoidance test. During acquisition trial, one hour before this test, mice were treated with APN (3 or 10 mg/kg, i.p.) and, 30 min later, mice were injected with vehicle or SCO (1 mg/kg, i.p.). Effect of APN on the SCO-induced learning and memory deficit was monitored based on the step-through latency. Data are presented as mean ± SEM (). Significant difference between the groups: , vehicle-treated control versus SCO alone group; and , SCO alone group versus APN-treated group in combination with SCO.