Immunoregulation of Shenqi Fuzheng Injection Combined with Chemotherapy in Cancer Patients: A Systematic Review and Meta-Analysis

Table 2

The detailed safety evaluation outcome in combination medication of SQI and chemotherapy agents.

Cancer

Gastrointestinal reaction

Routine blood indexes

LI

RI

KPS

Peripheral nerve toxicity

Oral ulcer

Hair loss

Fever

Phlebitis

HFS

NV

Anorexia

Diarrhea

WBC↓

RBC↓

HGB↓

PLT↓

NEU↓

Lung cancer

8 [16, 19, 20, 23, 24, 28–30]

5 [13, 14, 30, 33, 34]

6 [16, 19, 20, 23, 29, 30]

13 [16, 18–20, 22, 23, 26, 28–31, 33, 34]

N

11 [19, 20, 22–24, 26, 28–31, 33]

11 [19, 20, 22–24, 26, 28–31, 33]

N

1 [22]

2 [16, 22]

10 [17–19, 21, 22, 24, 29, 30, 32, 33]

1 [20]

N

N

2 [16, 28]

N

N

Digestive tract cancer

14 [37–39, 41, 43, 44, 46–50, 52–54]

5 [38, 41, 43, 44, 48]

10 [38, 41, 43, 44, 46–49, 53, 54]

12 [36, 37, 40, 46, 47, 49–54, 56]

1 [36]

6 [36, 37, 40, 49, 53, 56]

12 [36, 37, 39, 40, 46, 47, 49, 51–54, 56]

N

11 [37, 43, 44, 46–52, 54]

8 [37, 43, 44, 46, 48, 49, 52, 54]

10 [35–37, 42, 46, 47, 49, 50, 52, 54]

4 [38, 39, 47, 54]

2 [46, 54]

3 [43, 46, 54]

2 [46, 52]

N

2 [43, 46]

Breast cancer

3 [8, 57, 61]

1 [8]

2 [8, 61]

5 [8, 57, 58, 60, 61]

N

3 [8, 57, 58]

3 [8, 58, 61]

N

2 [57, 61]

2 [57, 61]

3 [57, 60, 61]

N

N

2 [57, 61]

N

1 [61]

N

NV: nausea and vomiting; LI: liver injury; RI: renal injury; KPS: Karnofsky performance score; WBC: white blood cell; RBC: red blood cell; HGB: hemoglobin; PLT: platelet; NEU: neutrophil; HFS: hand-foot syndrome; N: not mentioned.