TY - JOUR A2 - Quintans-JĂșnior, Lucindo J. AU - Yao, Weijie AU - Yang, Xinwei AU - Zhu, Jiayue AU - Gao, Biane AU - Liu, Renhui AU - Xu, Liping PY - 2017 DA - 2017/11/21 TI - Tang-Luo-Ning, a Traditional Chinese Medicine, Inhibits Endoplasmic Reticulum Stress-Induced Apoptosis of Schwann Cells under High Glucose Environment SP - 5193548 VL - 2017 AB - Tang-Luo-Ning (TLN) has a definite effect in the clinical treatment of diabetic peripheral neuropathy (DPN). Schwann cells (SCs) apoptosis induced by endoplasmic reticulum stress (ER stress) is one of the main pathogeneses of DPN. This study investigates whether TLN can inhibit SCs apoptosis by inhibiting ER stress-induced apoptosis. Our previous researches have demonstrated that TLN could increase the expression of ER stress marker protein GRP78 and inhibited the expression of apoptosis marker protein CHOP in ER stress. In this study, the results showed that TLN attenuated apoptosis by decreasing Ca2+ level in SCs and maintaining ER morphology. TLN could decrease downstream proteins of CHOP including GADD34 and Ero1α, while it increased P-eIF2α and decreased the upstream proteins of CHOP including P-IRE1α/IRE1α and XBP-1, thereby reducing ER stress-induced apoptosis. SN - 1741-427X UR - https://doi.org/10.1155/2017/5193548 DO - 10.1155/2017/5193548 JF - Evidence-Based Complementary and Alternative Medicine PB - Hindawi KW - ER -