Tang-Luo-Ning, a Traditional Chinese Medicine, Inhibits Endoplasmic Reticulum Stress-Induced Apoptosis of Schwann Cells under High Glucose Environment
TLN can decrease the expression of P-IRE1α/IRE1α and XBP-1 in high glucose-induced RSC96 cells. (a) Images of P-IRE1α and IRE1α relative protein level measured by Western blot, normalized to β-actin. (b) Images of XBP-1 relative protein level measured by high content analysis; images were viewed at a magnification of 10x. ((c)–(f)) Summarized data of P-IRE1α, IRE1α, P-IRE1α/IRE1α, and XBP-1, normalized as fold change of 25 mM glucose group. Data were analyzed by one-way ANOVA followed by least significant difference. Data were shown as mean ± SEM (). and versus 25 mM glucose; and versus 150 mM glucose.
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