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Evidence-Based Complementary and Alternative Medicine
Volume 2017, Article ID 5294890, 15 pages
Research Article

A Pilot Randomized, Controlled Study of Nanocrystalline Silver, Manuka Honey, and Conventional Dressing in Healing Diabetic Foot Ulcer

1O&T Department, Queen Elizabeth Hospital, Kowloon, Hong Kong
2Department of Nursing, The Hong Kong Polytechnic University, Kowloon, Hong Kong
3School of Nursing, Tung Wah College, Kowloon, Hong Kong
4Department of Health Technology & Informatics, The Hong Kong Polytechnic University, Kowloon, Hong Kong
5Faculty of Liberal Arts and Social Sciences, The Education University of Hong Kong, Tai Po, Hong Kong
6Ginger Knowledge Transfer and Consultancy Limited, Kowloon, Hong Kong

Correspondence should be addressed to Ka-Kit Tsang; moc.rotagivten@3gnastkk

Received 25 September 2016; Revised 3 December 2016; Accepted 13 December 2016; Published 25 January 2017

Academic Editor: Elia Ranzato

Copyright © 2017 Ka-Kit Tsang et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Nanocrystalline silver (nAg) and Manuka honey (MH) dressing have increasing popularity for treating diabetic foot ulcer (DFU). This study was an open-label randomized controlled trial with three parallel groups’ design in examining the preliminary effectiveness of nAg against MH and conventional dressing in healing DFU in terms of ulcer healing, ulcer infection, and inflammation. 31 participants (11 in the nAg group, 10 in the MH group, and 10 in the convention group) diagnosed with type 2 diabetes were enrolled. Wound cleaning, debridement, and topical dressing application were performed according to the group allocation in each visit at weeks 1, 2, 3, 4, 6, 8, 10, and 12. The results found that the proportions of complete ulcer healing were 81.8%, 50%, and 40% in the nAg, MH, and conventional groups, respectively. The ulcer size reduction rate was potentially higher in the nAg group (97.45%) than the MH group (86.21%) and the conventional group (75.17%). In bacteriology, nAg showed a greater rate of microorganism reduction although it was not significant. To conclude, nAg alginate was potentially superior to MH and conventional dressing in healing diabetic foot ulcer in terms of ulcer size reduction rate.