Salidroside Protects against MPP+-Induced Neuronal Injury through DJ-1-Nrf2 Antioxidant Pathway

Figure 3

Effect of Sal on key antioxidant regulator expression in MPP+-treated SH-SY5Y cells. SH-SY5Y cells were pretreated with 25–100 μM Sal for 24 h and then exposed to 500 μM MPP+ for an additional 24 h. ((a) and (b)) mRNA expression of DJ-1, Nrf2, GCLc, SOD1, and SOD2 was determined and statistical analysis was showed. ((c) and (d)) Protein expression of DJ-1, Nrf2, GCLc, SOD1, and SOD2 was determined and statistical analysis was showed. , compared with control. , compared with MPP⁺.

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