Evidence-Based Complementary and Alternative Medicine / 2017 / Article / Fig 4

Research Article

Rhodiolae Kirliowii Radix et Rhizoma and Crataegus pinnatifida Fructus Extracts Effectively Inhibit BK Virus and JC Virus Infection of Host Cells

Figure 4

Effect of Rhodiolae Kirliowii Radix et Rhizoma and Crataegus pinnatifida Fructus treatments on viral protein and gene expression. (a and b) The presence of BKPyV LT or JCPyV VP1 protein was detected by immunofluorescence assay after treatment with Rhodiolae Kirliowii Radix et Rhizoma (a) or Crataegus pinnatifida Fructus (b) extract. Viral protein expression after treatment with herb extract was calculated as a percentage of the amount observed for the vehicle control, and the results were used for standard deviation. (c and d) BKPyV or JCPyV late VP1 gene expression was determined by quantitative real-time PCR after treatment with Rhodiolae Kirliowii Radix et Rhizoma (c) or Crataegus pinnatifida Fructus (d) extract. Viral late gene expression after treatment was calculated as a percentage of the amount observed for the vehicle control, and the results were used for standard deviation.
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