Investigating the Mechanisms of Action of Depside Salt from Salvia miltiorrhiza Using Bioinformatic Analysis

Table 1

MLB-associated genes, RA-associated genes, and LA-associated genes searched from the GeneCards, STICH, SuperTarget, PubChem, and CTD databases.

Database	MLB		RA		LA
	Count	Symbol	Count	Symbol	Count	Symbol
GeneCards	6	NOS2, NOS3, AKR1B1, XDH, PLOD1, PTPN1	33	SLC16A1, PTGS2, TNF, ALOX5, IL1B, TAT, JUN, BCL2, CXCL8, CCL11, LCK, FOS, CCL2, CREB1, ERVK-6, PIK3CG, NFKB1, PLCG1, IKBKB, SHC1, MAP2K1, CCL3, RELA, GRB2, XIAP, EEF1A1, CCR3, CXCL2, BIRC2, ZAP70, BIRC3, ITK, MIR155	8	NOS2, NOS3, AKR1B1, XDH, PLOD1, PTPN1, SPTLC1, SPTLC2
STICH	8	IL15, IL2, IL4, KCNMA1, KCNU1, MAPK8, RRAGA, RRAGB	7	CCR3, FOS, IKBKB, IL2, LCK, PARG, PROCR	0	/
SuperTarget	0	/	5	ALDR, C1R, HYAL1, LCK, TYRO	0	/
PubChem	0	/	10	PROCR, PARG, TNF, ADAM17, SERPINE1, MAOB, MAOA, IL1B, DNMT1, COL1A1	0	/
CTD	7	IFNG, IL1B, CASP3, NFE2L2, SIRT1, CAT, RELA	21	PROCR, ADAM17, IL1B, CXCL1, IL6, TNF, SERPINE1, AIFM1, CASP3, COL1A1, COMT, DNMT1, FN1, GPT, MAOA, MAOB, NOS2, NOS3, OGG1, PARG, RELA	1	XDH

MLB, magnesium lithospermate B; RA, rosmarinic acid; LA, lithospermic acid, STICH, Search Tool for Interacting Chemicals; CTD, Comparative Toxicogenomics Database.