Review Article

Medicinal Plants for the Treatment of Local Tissue Damage Induced by Snake Venoms: An Overview from Traditional Use to Pharmacological Evidence

Table 2

List of medicinal plants with inhibitory potential against local effects induced by Naja snakes.

Plant namePart usedSnake venomInhibited activitiesReference(s)
In vitroIn vivo

Acanthaceae
Andrographis stenophyllaLeafN. najaHemorrhage[83]
Amaranthaceae
Pupalia lappaceaHerbalN. nigricollisSVH[82]
Amaryllidaceae
Allium BulbN. n. karachiensisPLA2[84]
Allium BulbN. n. karachiensisPLA2[84]
Anacardiaceae
Lannea acidaCortexN. nigricollisSVH[82]
Pistacia chinensis subsp.GallN. n. karachiensisPLA2[84]
Sclerocarya birreaCortexN. nigricollisSVH[82]
Spondias Cortex, radixN. nigricollisSVH[82]
Annonaceae
Annona CortexN. nigricollisSVH[82]
Apiaceae
Cuminum cyminumSeedN. n. karachiensisPLA2[84]
Apocynaceae
Acokanthera oppositifoliaRadixN. nigricollisSVH
Calotropis Flower, latexN. n. karachiensisPLA2[84]
Strophanthus sarmentosusFoliumN. nigricollisSVH[82]
Strophanthus speciosusRadixN. nigricollisSVH[82]
Tylophora Leaf, rootN. najaPLA2Hemorrhage[85]
Araceae
Colocasia esculentaTuberN. nigricollisSVH[82]
Araliaceae
Polyscias fulvaCortexN. nigricollisSVH[82]
Aristolochiaceae
Aristolochia Leaf, rootN. najaPLA2Hemorrhage[85]
Asteraceae
Callilepis laureolaRadixN. nigricollisSVH[82]
Bignoniaceae
Kigelia africanaCortex, foliumN. nigricollisSVH[82]
Tecoma stans (syn. Stenolobium stans)RootN. n. karachiensisPLA2[84]
Bixaceae
Cochlospermum tinctoriumRadixN. nigricollisSVH[82]
Boraginaceae
Cordia macleodiiBarkN. najaEdema, hemorrhage, necrosis[86]
Trichodesma Whole plantN. n. karachiensisPLA2[84]
Capparaceae
Capparis tomentosaRadixN. nigricollisSVH[82]
Colchicaceae
Gloriosa RadixN. nigricollisSVH[82]
Combretaceae
Combretum FoliumN. nigricollisSVH[82]
Guiera senegalensisRadixN. nigricollisSVH[82]
Terminalia BarkN. n. karachiensisPLA2[84]
Convolvulaceae
Ipomoea rubensSeedN. nigricollisSVH[82]
Cucurbitaceae
Citrullus FruitN. n. karachiensisPLA2[84]
Luffa cylindrica (syn. Luffa aegyptiaca)LeafN. nigricollisProteolytic[87]
Momordica FruitN. n. karachiensisPLA2[84]
Ebenaceae
Diospyros mespiliformisCortexN. nigricollisSVH[82]
Euphorbiaceae
Alchornea laxifloraCortexN. nigricollisSVH[82]
Clutia cordataRadixN. nigricollisSVH[82]
Euphorbia Whole plantN. najaPLA2, proteolytic, SVHEdema[88]
Jatropha Leaf, root, stemN. najaPLA2[89]
Jatropha Leaf, root, stemN. najaPLA2[89]
Manihot foetida (syn. Jatropha foetida)Leaf, stemN. najaPLA2[89]
Fabaceae
Abrus RadixN. nigricollisSVH[82]
Argyrolobium stipulaceumRadixN. nigricollisSVH[82]
Bauhinia thonningiiCortex, radixN. nigricollisSVH[82]
Bauhinia RootN. n. karachiensisPLA2[84]
Bobgunnia madagascariensis (syn. Swartzia madagascariensis)Folium, radixN. nigricollisSVH[82]
Burkea africanaCortexN. nigricollisSVH[82]
Cullen corylifolium (syn. Psoralea corylifolia)SeedN. n. karachiensisPLA2[84]
Dichrostachys cinereaFoliumN. nigricollisSVH[82]
Entada africanaRadixN. nigricollisSVH[82]
Mimosa RootN. kaouthia, N. najaPLA2, proteolytic, SVHEdema, myotoxicity[9092]
Parkia biglobosaCortex, stem barkN. nigricollisCytotoxicity against muscle cells, SVH[82, 93]
Stylosanthes erectaFoliumN. nigricollisSVH[82]
Tamarindus Folium, radixN. nigricollisSVH[82]
Gentianaceae
Enicostema axillare (syn. Enicostema hyssopifolium)#Whole plantN. n. karachiensisPLA2[84]
Hypericaceae
Psorospermum corymbiferumCortex, radixN. nigricollisSVH[82]
Lamiaceae
Leucas Leaf, root, whole plantN. najaPLA2, proteolytic, SVHHemorrhage[85, 94]
Leucas cephalotes (syn. Leucas capitata)#Whole plantN. n. karachiensisPLA2[84]
Leucas martinicensisNDN. nigricollisSVH[82]
Ocimum tenuiflorum (syn. Ocimum sanctum)#Whole plantN. n. karachiensisPLA2[84]
Rotheca myricoides (syn. Clerodendrum myricoides)CortexN. nigricollisSVH[82]
Teucrium kraussiiAerial parts, cortexN. nigricollisSVH[82]
Volkameria glabra (syn. Clerodendrum glabrum)RadixN. nigricollisSVH[82]
Lauraceae
Cassytha filiformisHerbalN. nigricollisSVH[82]
Loganiaceae
Strychnos innocuaFoliumN. nigricollisSVH[82]
Strychnos SeedN. kaouthiaPLA2[95]
Malvaceae
Althaea officinalisRootN. n. karachiensisPLA2[84]
Dombeya quinquesetaCortexN. nigricollisSVH[82]
Grewia mollisCortex, folium, radixN. nigricollisSVH[82]
Sterculia setigeraCortexN. nigricollisSVH[82]
Waltheria indicaRadixN. nigricollisSVH[82]
Menispermaceae
Cissampelos mucronataHerbalN. nigricollisSVH[82]
Moraceae
Ficus platyphyllaFoliumN. nigricollisSVH[82]
Olacaceae
Ximenia americanaFoliumN. nigricollisSVH[82]
Pedaliaceae
Ceratotheca sesamoidesHerbalN. nigricollisSVH[82]
Peraceae
Clutia pulchellaRadixN. nigricollisSVH[82]
Phyllanthaceae
Flueggea virosa (syn. Securinega virosa)RadixN. nigricollisSVH[82]
Pinaceae
Cedrus deodaraBarkN. n. karachiensisPLA2[84]
Pinus OleoresinN. n. karachiensisPLA2[84]
Poaceae
Cymbopogon schoenanthusRadixN. nigricollisSVH[82]
Primulaceae
Maesa CortexN. nigricollisSVH[82]
Rhamnaceae
Ziziphus mucronataRadixN. nigricollisSVH[82]
Ziziphus spina-christiCortexN. nigricollisSVH[82]
Rubiaceae
Crossopteryx febrifugaCortexN. nigricollisSVH[82]
Pentanisia prunelloidesRadixN. nigricollisSVH[82]
Pentas zanzibaricaFoliumN. nigricollisSVH[82]
Rubia Stem
Rutaceae
Citrus FruitN. n. karachiensisPLA2[84]
Zanthoxylum capenseRadixN. nigricollisSVH[82]
Sapindaceae
Paullinia pinnataFoliumN. nigricollisSVH[82]
Sapindus mukorossiFruitN. n. karachiensisPLA2[84]
Solanaceae
Nicotiana rusticaLeafN. nigricollisProteolytic[87]
Schwenckia americanaFoliumN. nigricollisSVH[82]
Thymelaeaceae
Gnidia anthylloidesRadixN. nigricollisSVH[82]
Gnidia kraussianaRadixN. nigricollisSVH[82]
Gnidia splendensRadixN. nigricollisSVH[82]
Verbenaceae
Lantana trifoliaCortexN. nigricollisSVH[82]
Vitaceae
Cissus populneaStemN. nigricollisSVH[82]
Zingiberaceae
Zingiber RhizomeN. n. karachiensisPLA2[84]
Zygophyllaceae
Fagonia creticaLeaf, stemN. n. karachiensisPLA2[84]

ND = information not described in the work; PLA2 = snake venom phospholipase A2; SVH = snake venom hyaluronidase. #Vegetal species with related folk use as antiophidic agents, as showed in Table 1. Studies where inhibitory activity was assessed only by preincubation of venom with extract (see Section 4.1 for details).